[1]谭妙,程延,刘祯垚,等.基于网络药理学探讨祛瘀生新胶囊治疗股骨头坏死的作用机制[J].西部中医药,2025,38(02):68-74.[doi:10.12174/j.issn.2096-9600.2025.02.16]
　TAN Miao,CHENG Yan,LIU Zhenyao,et al.Network Pharmacology-based Discussion on the Mechanism of Stasis-resolving New-generating Capsules for Osteonecrosis of the Femoral Head[J].Western Journal of Traditional Chinese Medicine,2025,38(02):68-74.[doi:10.12174/j.issn.2096-9600.2025.02.16]
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基于网络药理学探讨祛瘀生新胶囊治疗股骨头坏死的作用机制()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
38
期数:
2025年02期
页码:
68-74
栏目:
二次研究
出版日期:
2025-02-15

文章信息/Info

Title:
Network Pharmacology-based Discussion on the Mechanism of Stasis-resolving New-generating Capsules for Osteonecrosis of the Femoral Head
作者:
谭妙1,2, 程延3, 刘祯垚1,4, 徐鹏1,5, 王明明1,6
1.陕西中医药大学，陕西 咸阳 712000
2.晋江市中医院，福建 晋江 362200
3.陕西省中医医院，陕西 西安 710000
4.西安宝石花长庆医院，陕西 西安 710000
5.西北大学第一医院，陕西 西安 710000
6.西安市长安区医院，陕西 西安 710000
Author(s):
TAN Miao1,2, CHENG Yan3, LIU Zhenyao1,4, XU Peng1,5, WANG Mingming1,6
1.Shaanxi University of Chinese Medicine, Xianyang 712000, China
2.Jinjiang Hospital of Traditional Chinese Medicine, Jinjiang 362200, China
3.Shaanxi Provincial TCM Hospital, Xi’an 710000, China
4.Gem Flower Xi’an Changqing Staff Hospital, Xi’an 710000, China
5.Northwest University First Hospital, Xi’an 710000, China
6.Xi’an Chang’an District Hospital, Xi’an 710000, China
关键词:
股骨头坏死; 祛瘀生新胶囊; 网络药理学
Keywords:
osteonecrosis of the femoral head; stasis-resolving new-generating capsules; network pharmacology
分类号:
R274.9
DOI:
10.12174/j.issn.2096-9600.2025.02.16
文献标志码:
A
摘要:
目的利用网络药理学方法探讨祛瘀生新胶囊治疗股骨头坏死（osteonecrosis of the femoral head，ONFH）的作用机制。 方法通过中药系统药理学数据库与分析平台（traditional Chinese medicine systems pharmacology database and analysis platform，TCMSP）筛选祛瘀生新胶囊6味中药的活性成分及其靶点，根据ADME筛选中药有效活性成分；通过人类基因数据库（the human gene database，GeneCards）、在线人类孟德尔遗传数据库（online mendelian inheritance in man，OMIM）、DisGeNet数据库筛选ONFH的疾病靶点；取药物和疾病交集靶点，利用STRING平台进行蛋白质相互作用分析，构建蛋白-蛋白互作（protein-protein interactions，PPI）网络；利用Metascape数据库对核心靶点进行基因本体论（gene ontology，GO）与京都基因与基因组百科全书（kyoto encyclopedia of genes and genomes，KEGG）富集分析；运用CytoScape 3.8.2软件构建成分-靶点-疾病网络。 结果筛选得到祛瘀生新胶囊36个有效活性成分和203个相应靶点蛋白；ONFH疾病相关靶点2992个，相交的靶点基因134个；核心有效成分为槲皮素、山柰酚、7-O-甲基异鼠李糖醇等；核心靶点包括PTGS2、PTGS1、NCOA2、PRSS1、RXRA等；主要通路包括糖尿病并发症中的AGE-RAGE、IL-17、PI3K/AKT信号通路等。 结论祛瘀生新胶囊可通过多成分、多靶点、多通路防治ONFH。
Abstract:
ObjectiveTo discuss the mechanism of stasis-resolving new-generating (Quyu Shengxin) capsules in the treatment of osteonecrosis of the femoral head (ONFH) using network pharmacology. MethodsThe active ingredients and the targets of six herbs contained in the capsules were screened via traditional Chinese medicine systems pharmacology database and analysis platform (TCMSP), to screen the effective active ingredients of herbs according to ADME; GeneCards, OMIM and DisGeNet databases were applied to screen disease targets of ONFH; After taking the intersection of herbs and disease as the targets, protein-protein interaction analysis was carried out using STRING platform to construct the network of protein-protein interaction (PPI); GO and KEGG enrichment analysis of the core targets were performed utilizing Metascape database; CytoScape 3.8.2 software was applied to build ingredients-target-disease network. ResultsThe study has yielded 36 effective active ingredients and 203 corresponding targets protein of the capsules; involving 2992 ONFH - related targets, and 134 intersecting target genes; the core active ingredients contained quercetin, rutin and 7-O-methylisomellitol; the core targets covered PTGS2, PTGS1, NCOA2, PRSS1 and RXRA; and the main pathways included AGE-RAGE, IL-17 and PI3K/AKT signaling pathways in diabetic complications. ConclusionThe capsules could prevent and treat ONFH via many ingredients, many targets and many pathways.

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备注/Memo

备注/Memo:
谭妙（1995—），女，硕士学位，医师。研究方向：中医骨伤科学。陕西省科技计划项目（2015SF079）；陕西省中医药管理局科研课题（2021-GJ-LC011）；陕西省中医药研究院/陕西省中医医院院级“苗圃培育计划”项目（2021-23）。
更新日期/Last Update: 2025-02-15