[1]史振华,王晓萍,张朋威,等.基于痰瘀互结探讨股骨头坏死的病因病机及临床应用[J].西部中医药,2026,39(02):26-29.[doi:10.12174/j.issn.2096-9600.2026.02.07]
　SHI Zhenhua,WANG Xiaoping,ZHANG Pengwei,et al.The Etiology and the Pathogenesis of ONFH and Its Clinical Application Based on Phlegm-Stasis Binding[J].Western Journal of Traditional Chinese Medicine,2026,39(02):26-29.[doi:10.12174/j.issn.2096-9600.2026.02.07]
点击复制

基于痰瘀互结探讨股骨头坏死的病因病机及临床应用()

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
39
期数:
2026年02期
页码:
26-29
栏目:
学术探讨
出版日期:
2026-02-15

文章信息/Info

Title:
The Etiology and the Pathogenesis of ONFH and Its Clinical Application Based on Phlegm-Stasis Binding
作者:
史振华1, 王晓萍2, 张朋威1, 高海源1, 杨星1
1.甘肃中医药大学，甘肃 兰州 730000
2.甘肃省中医院，甘肃 兰州 730050
Author(s):
SHI Zhenhua1, WANG Xiaoping2, ZHANG Pengwei1, GAO Haiyuan1, YANG Xing1
1.Gansu University of Chinese Medicine, Lanzhou 730000, China
2.Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China
关键词:
股骨头坏死; 痰瘀互结; 病因病机; 病理变化; 化痰祛瘀法
Keywords:
osteonecrosis of the femoral head; phlegm-stasis binding; the etiology and pathogenesis; pathological changes; phlegm-resolving stasis-eliminating method
分类号:
R274.9
DOI:
10.12174/j.issn.2096-9600.2026.02.07
文献标志码:
A
摘要:
对痰、瘀等因素与股骨头坏死（osteonecrosis of the femoral head，ONFH）的相关病因病机以及化痰祛瘀法治疗ONFH的机制研究进行梳理，指出痰瘀互结是ONFH常见致病因素，亦是ONFH重要的病因病机，痰瘀互结能够诱发股骨头脂代谢紊乱，阻碍股骨头血液供应，影响骨髓微环境变化，引发骨细胞代谢失衡，且贯穿于ONFH发生发展的全过程。中医药在辨证施治的基础上结合“化痰祛瘀”法治疗ONFH可能疗效更佳；同时应注重整体观念，考虑痰瘀形成的病机，从肝、脾、肾等多脏腑进行综合论治。
Abstract:
By reviewing the correlation between the etiology and pathogenesis of ONFH with factors such as phlegm and stasis, the study on the mechanism of phlegm-resolving stasis-eliminating method in the treatment of ONFH, it was pointed out that phlegm-stasis binding served as the common pathogenic factor for ONFH, and the important cause and pathogenesis of the disease. Phlegm-stasis binding could induce lipid metabolism disorders of the femoral head, impair blood supply to the femoral head, and trigger changes in the bone marrow microenvironment, resulting in bone cell metabolic imbalance, throughout the entire process of ONFH occurrence and development. On the foundation of syndrome differentiation and treatment, the combination of TCM and phlegm-resolving stasis-eliminating method is effective in treating ONFH; meanwhile, the concept of holism should be emphasized, and the pathogenesis of phlegm-stasis formation should be considered, so as to treat the disease from liver, spleen and kidney comprehensively.

相似文献/References:

[1]梁 周,王大伟△,陆兰兰,等.通脉生骨Ⅱ号方对激素性股骨头缺血性坏死BGP及VEGF表达的影响*[J].西部中医药,2012,25(10):44.
　LIANG Zhou,WANG Da-wei,LU Lan-lan,et al.Influence of TongMai ShengGu Recipe II on Expressions of BGP and VEGF in Glucocorticoid-induced Avascular Necrosis of Femoral Head[J].Western Journal of Traditional Chinese Medicine,2012,25(02):44.
[2]李盛华,周明旺,潘文,等.酒精性股骨头坏死与中医体质类型的关系*[J].西部中医药,2014,27(03):80.
　LI Shenghua,ZHOU Mingwang,PAN Wen,et al.Exploration on the Relationship between Alcohol-induced Osteonecrosis Femoral Head and TCM Constitution Types[J].Western Journal of Traditional Chinese Medicine,2014,27(02):80.
[3]高鹏真,汪玉良.右归饮联合人工全髋置换术治疗激素性股骨头坏死价值探讨[J].西部中医药,2014,27(06):117.
　GAO Pengzhen,WANG Yuliang.Exploration on the Value of YouGui Drink and Total Hip Replacement in the Treatment for Steroid-induced Femoral Head Necrosis[J].Western Journal of Traditional Chinese Medicine,2014,27(02):117.
[4]柳海平,周明旺,李盛华,等.酒精性股骨头坏死高发中医体质类型研究[J].西部中医药,2017,30(01):51.
　LIU Haiping,ZHOU Mingwang,LI Shenghua,et al.Study on TCM Constitutions of High-incidence Alcohol-induced Osteonecrosis of Femoral Head[J].Western Journal of Traditional Chinese Medicine,2017,30(02):51.
[5]卢宏涛,李虹静,刘康.川芎嗪注射液联合髓芯减压术治疗SteinbergⅡ期股骨头坏死60例[J].西部中医药,2017,30(08):111.
　LU Hongtao,LI Hongjing,LIU Kang.Ligustrazine Injection Combined with Core Decompression in Treating 60 Cases of Femoral Head Necrosis at SteinbergII Stage[J].Western Journal of Traditional Chinese Medicine,2017,30(02):111.
[6]魏玉娇,何玲,郭小荣,等.髓芯减压联合生骨再造丸对兔激素性股骨头坏死骨组织BMP-2与VEGF mRNA的影响[J].西部中医药,2018,31(09):34.
　WEI Yujiao,HE Ling,GUO Xiaorong,et al.Impact of Core Decompression and ShengGu ZaiZao Pills on BMP-2 and VEGF mRNA of Bone Tissue of Rabbit with Steroid-induced Femoral Head Necrosis[J].Western Journal of Traditional Chinese Medicine,2018,31(02):34.
[7]石威,张俊忠,解鹏超,等.基于网络药理学和分子对接探析淫羊藿-牛膝药对治疗股骨头坏死的作用机制[J].西部中医药,2022,35(04):35.[doi:10.12174/j.issn.2096-9600.2022.04.09]
　SHI Wei,ZHANG Junzhong,XIE Pengchao,et al.Study on the Mechanism of Yinyanghuo-Niuxi Drug Pair in Treating Femoral Head Necrosis Based on Network Pharmacology and Molecular Docking[J].Western Journal of Traditional Chinese Medicine,2022,35(02):35.[doi:10.12174/j.issn.2096-9600.2022.04.09]
[8]温明韬,梁学振,许波,等.基于网络药理学探讨杜仲-牛膝治疗股骨头坏死的分子机制[J].西部中医药,2021,34(08):76.[doi:10.12174/j.issn.2096-9600.2021.08.17]
　WEN Mingtao,LIANG Xuezhen,XU Bo,et al.Molecular Mechanism of Duzhong-niuxi in Treating Osteonecrosis of the Femoral Head Based on Network Pharmacology[J].Western Journal of Traditional Chinese Medicine,2021,34(02):76.[doi:10.12174/j.issn.2096-9600.2021.08.17]
[9]郭召平,苏琴,黄天生.化痰助运通络方治疗痰瘀互结型非酒精性脂肪肝肝纤维化临床研究[J].西部中医药,2021,34(05):122.[doi:10.12174/j.issn.2096-9600.2021.05.31]
　GUO Zhaoping,SU Qin,HUANG Tiansheng.Clinical Study on Treating Non Alcoholic Fatty Liver Fibrosis of Phlegm and Blood Stasis Pattern by Resolving-phlegm Promoting-transportation Dredging-collateral Prescription[J].Western Journal of Traditional Chinese Medicine,2021,34(02):122.[doi:10.12174/j.issn.2096-9600.2021.05.31]
[10]张乘源,尹纪光,吴伟山,等.基于“久病入络”理论论治股骨头坏死[J].西部中医药,2023,36(04):39.[doi:10.12174/j.issn.2096-9600.2023.04.09]
　ZHANG Chengyuan,YIN Jiguang,WU Weishan,et al.Treatment of Osteonecrosis of the Femoral Head Based on the Theory of "Pathogen Intruding into Collateral in Protracted Disease"[J].Western Journal of Traditional Chinese Medicine,2023,36(02):39.[doi:10.12174/j.issn.2096-9600.2023.04.09]

备注/Memo

备注/Memo:
国家自然科学基金（82360942，82060876）；甘肃省科技计划项目（18JR2FA009）。史振华（1998—），男，在读硕士研究生。研究方向：中医药防治骨与关节疾病。
更新日期/Last Update: 2026-02-15