[1]蔡贞浩,戴国华,张嘉禛,等.芪参益气滴丸治疗慢性心力衰竭患者终点事件发生情况的队列研究[J].西部中医药,2022,35(12):118-121.[doi:10.12174/j.issn.2096-9600.2022.12.26]
 CAI Zhenhao,DAI Guohua,ZHANG Jiazhen,et al.A Cohort Study of End Point Events in Patients with Chronic Heart Failure by Qishen Qiyi Dropping Pills[J].Western Journal of Traditional Chinese Medicine,2022,35(12):118-121.[doi:10.12174/j.issn.2096-9600.2022.12.26]
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芪参益气滴丸治疗慢性心力衰竭患者终点事件发生情况的队列研究
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
35
期数:
2022年12期
页码:
118-121
栏目:
出版日期:
2022-12-15

文章信息/Info

Title:
A Cohort Study of End Point Events in Patients with Chronic Heart Failure by Qishen Qiyi Dropping Pills
作者:
蔡贞浩1, 戴国华2, 张嘉禛1, 姚久秀1, 赵雪1
1.山东中医药大学,山东 济南 250014
2.山东中医药大学附属医院
Author(s):
CAI Zhenhao1, DAI Guohua2, ZHANG Jiazhen1, YAO Jiuxiu1, ZHAO Xue1
1.Shandong University of Traditional Chinese Medicine, Jinan 250014, China
2.Affiliated Hospital to Shandong University of Traditional Chinese Medicine
关键词:
心力衰竭慢性芪参益气滴丸终点事件队列研究
Keywords:
heart failure chronicdropping pillsend point eventscohort study
分类号:
R541.6+1
DOI:
10.12174/j.issn.2096-9600.2022.12.26
文献标志码:
A
摘要:
目的探讨芪参益气滴丸的应用与慢性心力衰竭患者终点事件发生情况的相关性。 方法采用回顾性队列研究设计,定义暴露组为使用芪参益气滴丸≥28天者,非暴露组为<28天者,纳入潍坊市中医医院、淄博市中医医院慢性心力衰竭患者,随访其出院后芪参益气滴丸的使用情况及终点事件的发生情况,采用多因素Logistic回归分析法分析芪参益气滴丸使用情况与终点事件发生情况的相关性。 结果研究共纳入884例慢性心力衰竭患者,完成随访736例,失访148例;暴露组143例,非暴露组593例;用于观测的终点事件发生情况为1年内心衰再入院206例、心源性死亡147例;回归分析显示强暴露、利尿剂、硝酸酯类药物、神经内分泌机制类药物是心源性死亡的保护因素,洋地黄类药物是一年内心力衰竭再入院的保护因素,同时是心源性死亡的相关因素。年龄是心源性死亡的危险因素,合并糖尿病是心源性死亡的危险因素,合并冠心病是1年内心力衰竭再入院的危险因素。 结论慢性心力衰竭患者使用芪参益气滴丸≥3个月能够降低随访期间心源性死亡的风险。
Abstract:
ObjectiveTo survey the correlation between the application of Qishen Yiqi dropping pills and the incidents of end point events in patients with chronic heart failure (CHF). MethodsA retrospective cohort study design was adopted, defining the patients who used Qishen Yiqi dropping pills more than 28 days the exposure group, and the ones who used the medicine less than 28 days as non-expousure group, and CHF patients are enrolled from Weifang hospital of TCM and Zibo hospital of TCM, who are followed up after discharge to explore the correlation between the application of Qishen Yiqi dropping pills and the occurrence of end point events in patients. ResultsIn the study, 884 CHF patients were enrolled, 736 cases were followed up and 148 ones were lost to follow up; 143 cases were of exposure group and 593 ones of non exposure group; the occurrence of end point events for observation was that 206 patients were readmitted because of heart failure within one year and 147 ones passed away because of cardiac death; regression analysis indicated that strong exposure, diuretics, nitrate esters neuroendocrine mechanism drugs are the protective factors for cardiac death, digitalis is the protective factor for heart failure readmission within one year, meanwhile, it's the relevant factor for cardiac death. Age is the risk factor for cardiac death, the complication with diabetes mellitus is the risk factor for cardiac death, the complication with coronary heart disease is the risk factor for heart failure readmission within one year. ConclusionThe application of Qishen Yiqi dropping pills in CHF patients more for three months could decrease the risk of cardiac death during the follow-up period.

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备注/Memo

备注/Memo:
蔡贞浩(1995—),男,硕士学位。研究方向:心血管疾病的临床和循证医学研究。国家自然科学基金(81774047)。
更新日期/Last Update: 2022-12-15