[1]刘畅,陈阳,叶佳,等.莪连颗粒对胃癌种植瘤裸鼠肿瘤生长及维甲酸相关孤核受体γt表达的影响[J].西部中医药,2023,36(07):17-19.[doi:10.12174/j.issn.2096-9600.2023.07.04]
　LIU Chang,CHEN Yang,YE Jia,et al.Effects of Elian Granules on Tumor Growth and RORγt Expression in Nude Mice with Gastric Cancer Implantation[J].Western Journal of Traditional Chinese Medicine,2023,36(07):17-19.[doi:10.12174/j.issn.2096-9600.2023.07.04]
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莪连颗粒对胃癌种植瘤裸鼠肿瘤生长及维甲酸相关孤核受体γt表达的影响
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
36
期数:
2023年07期
页码:
17-19
栏目:
出版日期:
2023-07-15

文章信息/Info

Title:
Effects of Elian Granules on Tumor Growth and RORγt Expression in Nude Mice with Gastric Cancer Implantation
作者:
刘畅1, 陈阳2, 叶佳1, 朱梅萍1
1.上海中医药大学附属曙光医院，上海 201203
2.上海中医药大学附属岳阳中西医结合医院，上海 200437
Author(s):
LIU Chang1, CHEN Yang2, YE Jia1, ZHU Meiping1
1.Shuguang Hospital Affiliated to Shanghai University of TCM, Shanghai 201203, China
2.Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China
关键词:
胃癌; 维甲酸相关孤核受体t; T细胞17; 莪连颗粒
Keywords:
gastric cancer; RORt; T helper cell 17; granules
分类号:
R965
DOI:
10.12174/j.issn.2096-9600.2023.07.04
文献标志码:
A
摘要:
目的探讨莪连颗粒对胃癌种植瘤裸鼠肿瘤生长及维甲酸相关孤核受体γt（retinoid-related orphan nuclear receptor γt，RORγt）表达的影响。 方法构建裸鼠人胃癌SGC-7901种植瘤模型，实验组予莪连颗粒灌胃，对照组予生理盐水灌胃。灌胃28天后处死小鼠并测定种植瘤体积及瘤重，计算抑瘤率。采用Western-Blot法检测肿瘤组织中RORγt表达。 结果实验组小鼠瘤重及肿瘤体积均低于对照组，抑瘤率为53.3%；实验组肿瘤组织RORγt表达较对照组减少。 结论莪连颗粒可抑制胃癌肿瘤生长，该作用可能与其抑制RORγt表达，减轻由辅助性T细胞17介导的免疫调节有关。
Abstract:
ObjectiveTo discuss the influence of Elian granule on tumor growth and the expression of RORγt in nude mice with transplanted gastric cancer. MethodsAfter constructing SGC-7901 implant tumor model of human gastric cancer in nude mice, the experiment group was drenched with Elian granules, and the control group with normal saline. After 28 days of gavage, to detect the tumor volume and tumor weight after the mice were sacrificed, to calculate tumor inhibition rate. Western-Blot was adopted to measure the expressions of RORγt in tumor tissue. ResultsThe experiment group was lower than the control group in tumor weight and tumor volume, the tumor inhibition rate was 53.3%; the expressions of RORγt in tumor tissue of the experiment group decreased compared with the control group. ConclusionElian granules could inhibit the growth of gastric cancer, and its effects might be related to that it could inhibit the expressions of RORγt and relieve the immunoregulation mediated by T helper cell 17 (Th17).

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备注/Memo

备注/Memo:
刘畅（1991—），女，硕士学位，主治医师。研究方向：中医药治疗消化系统疾病的临床及基础研究。首届全国名中医传承工作室建设项目（MZYGZS-2017003）。
更新日期/Last Update: 2023-07-15