[1]张义全,雷芳,陈亮.心脉隆注射液联合芪苈强心胶囊对老年慢性心力衰竭患者血清BNP、NF-κB及胱抑素C水平的影响[J].西部中医药,2018,31(02):1-5.
　ZHANG Yiquan,LEI Fang,CHEN Liang.Study on the Effects of XinMaiLong Injection Combined with QiLi QiangXin Capsules on the Levels of BNP, NF-κB and Cystatin C of the Elderly Suffering Chronic Heart Failure[J].Western Journal of Traditional Chinese Medicine,2018,31(02):1-5.
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心脉隆注射液联合芪苈强心胶囊对老年慢性心力衰竭患者血清BNP、NF-κB及胱抑素C水平的影响()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
31
期数:
2018年02期
页码:
1-5
栏目:
出版日期:
2018-02-15

文章信息/Info

Title:
Study on the Effects of XinMaiLong Injection Combined with QiLi QiangXin Capsules on the Levels of BNP, NF-κB and Cystatin C of the Elderly Suffering Chronic Heart Failure
文章编号:
1004-6852(2018)02-0001-05
作者:
张义全，雷芳，陈亮
重庆市高新区人民医院，重庆 401554
Author(s):
ZHANG Yiquan, LEI Fang, CHEN Liang
The People′s Hospital of Gaoxin District of Chongqing Municipality, Chongqing 401554, China
关键词:
心力衰竭; 慢性; 心脉隆注射液; 芪苈强心胶囊; 脑钠肽; 核因子κB; 血清胱抑素
Keywords:
heart failure;  chronic;  XinMaiLong injection;  QiLi QiangXin capsules;  BNP;  NF-κB;  Cys C
分类号:
R541.6+1
文献标志码:
A
摘要:
目的：探讨心脉隆注射液联合芪苈强心胶囊对老年慢性心力衰竭患者血清脑钠肽(BNP)、核因子κB(NF-κB)、血清胱抑素C(CysC)水平的影响。方法：选取66例老年慢性心力衰竭患者，随机分成观察组和对照组，每组33例。均予缓解病因和诱因、限盐限水、吸氧等基础治疗和利尿剂、血管紧张素转化酶抑制剂（ACEI）等常规治疗，对照组在此基础上予心脉隆注射液(5 mg/kg，2次/d)静滴，观察组在上述治疗基础上再予芪苈强心胶囊(4粒/次，3次/d)口服。治疗2周后，检测氧化应激指标、心功能相关指标，评估生活质量，比较临床疗效。结果：与治疗前比较，2组血浆丙二醛（MDA）水平降低(P＜0.01)，过氧化氢酶（CAT）、谷胱甘肽过氧化氢酶（GSH-Px）水平升高(P＜0.01)，BNP、NK-κB、CysC水平降低(P＜0.01)，左室舒张末期内径（LVEDD）、左室收缩末期内径（LVESD）降低(P＜0.05)，射血分数（EF）、心排血量（CO）升高(P＜0.05)，明尼苏达心衰生活质量表（MLHFQ）评分、Lee氏心衰评分降低(P＜0.05)，6分钟步行距离升高(P＜0.05)；与对照组比较，观察组MDA水平较低(P＜0.01)，CAT、GSH-Px水平较高(P＜0.01)，脑钠肽（BNP）、NF-κB、CysC水平较低(P＜0.01)，LVEDD、LVESD较低(P＜0.05)，EF、CO较高(P＜0.05)，MLHFQ评分、Lee氏心衰评分较低(P＜0.05)，6分钟步行距离较高(P＜0.05)，总有效率较高(P＜0.05)。结论：心脉隆注射液联合芪苈强心胶囊改善慢性心力衰竭患者心肌功能，抑制心肌重构，提高生活质量。
Abstract:
Objective: To discuss the effects of XinMaiLong injection combined with QiLi QiangXin capsules on the levels of BNP, NF-κB and Cystatin C(Cys C) of the elderly suffering chronic heart failure (CHF). Methods: Sixty-six elderly patients with CHF were chosen as the objects of the study, randomly separated into two groups, 33 cases each group. They accepted basic treatment including alleviating the cause and the remote cause, limiting salt and water, oxygen uptake and conventional treatment such as diuretics, ACEI and others, the control group received intravenous dripping of XinMaiLong injection (5 mg/kg, twice each day) on the foundation, and the experiment group orally took QiLi QiangXin capsules, four pills each time, three times each day. Clinical effects were compared by assessing quality of life, detecting oxidative stress indexes and the related indexes of heart function. Results: Compared with before treating, the levels of MDA in both groups decreased(P＜0.01), the levels of CAT and GSH-Px raised (P＜0.01), the levels of BNP, NF-κB and Cys C lowered (P＜0.01), LVEDD and LVESD decreased (P＜0.05), EF and CO raised (P＜0.05), MLHFQ and LEE′s heart scales decreased (P＜0.05), six minutes walking distance raised (P＜0.05); compared with the control group, in the observation group, MDA level was lower (P＜0.01), the levels of CAT and GSH-Px were higher (P＜0.01), the levels of BNP, NF-κB and Cys C were lower (P＜0.01), LVEDD and LVESD were lower (P＜0.05), EF and CO were higher (P＜0.05), MLHFQ and LEE′s heart scales were lower (P＜0.05), six minutes walking distance was higher (P＜0.05), total effective rate was higher (P＜0.05). Conclusion: XinMaiLong injection combined with QiLi QiangXin capsules could improve myocardial function, inhibit the reconstruction, raise quality of life of CHF patients.

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备注/Memo

备注/Memo:
收稿日期：2017-09-23 *基金项目：国家自然科学基金项目(编号81300140)；重庆市科委自然科学基金面上项目(编号CSTC2009BB5405)；重庆市卫生局医学科研计划项目(编号2013-2-010)。 作者简介：张义全(1966—)，男，副主任医师。研究方向：心内科疾病的临床治疗。
更新日期/Last Update: 2018-02-15