[1]孙曦,王洪旗,龚一竹,等.复方苦参注射液联合α-干扰素治疗慢性乙型肝炎55例[J].西部中医药,2018,31(12):95-97.
　SUN Xi,WANG Hongqi,GONG Yizhu,et al.Compound KuShen Injection and Interferon α-1b in Treating 55 Cases of Chronic Hepatitis B[J].Western Journal of Traditional Chinese Medicine,2018,31(12):95-97.
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复方苦参注射液联合α-干扰素治疗慢性乙型肝炎55例
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
31
期数:
2018年12期
页码:
95-97
栏目:
出版日期:
2018-12-15

文章信息/Info

Title:
Compound KuShen Injection and Interferon α-1b in Treating 55 Cases of Chronic Hepatitis B
文章编号:
1004-6852(2018)12-0095-03
作者:
孙曦，王洪旗，龚一竹，刘庆德，肖璐△
解放军第97医院感染病科，江苏 徐州 221000
Author(s):
SUN Xi, WANG Hongqi, GONG Yizhu, LIU Qingde, XIAO Lu△
Department of Infectious Disease, No.97 Hospital of PLA, Xuzhou 221000, China
关键词:
乙型肝炎; 慢性; 复方苦参注射液; 干扰素α
Keywords:
hepatitis B;  chronic;  compound KuShen injection;  IFα-1b
分类号:
R512.6+2
摘要:
目的：观察复方苦参注射液联合干扰素α治疗慢性乙型肝炎的临床疗效。方法：将110例患者随机分为2组。对照组在常规保肝、支持、对症治疗的基础上，注射用重组人干扰素α-1b，观察组同时给予复方苦参注射液静脉滴注，比较2组的临床治疗效果。结果：血清层黏连蛋白、透明质酸、Ⅲ型前胶原蛋白肽和Ⅳ型胶原及血清总胆红素、丙氨酸氨基转移酶、白蛋白治疗前后2组组内比较，差异有统计学意义(P＜0.05)；治疗后2组组间比较差异也有统计学意义(P＜0.05)。血清HBV-DNA转阴率、HBeAg转阴率观察组分别为81.8%(45/55)、40.0%(22/55)，对照组分别为63.6%(35/55)、18.2%(10/55)，2组比较差异均有统计学意义(P＜0.05)。结论：复方苦参注射液联合干扰素α可有效改善慢性乙型肝炎患者的肝功能，促进HBV-DNA和HBeAg转阴。
Abstract:
Objective：To observe clinical effects of compound KuShen injection and interferon α-1b (IFα-1b) in treating chronic hepatitis B. Methods: All 110 patients were randomized into two groups. The control group were injected with IFα-1b on the foundation of conventional liver-protecting, supportive and corresponding therapy, the observation group accepted intravenous injection of compound KuShen injection, clinical effects of both groups were compared. Results: The difference showed statistical meaning in the comparisons of serum laminin, hyaluronic acid, type Ⅲ procollagen peptide and type Ⅳ collagen, serum total bilirubin, alanine aminotransferase (AAT) and albumin within two groups before and after treating(P＜0.05); the difference showed statistical meaning in the comparisons between both groups after treating(P＜0.05). HBV DNA negative-conversion rate and HBeAg negative-conversion rate of the observation group were 81.8%(45/55) and 40.0%(22/55), while the rates of the control group were 63.6%(35/55) and 18.2%(10/55) respectively, and the difference showed statistical meaning (P＜0.05). Conclusion: Compound KuShen injection and IFα-1b could improve liver function of the patients suffering chronic hepatitis B, promote HBV DNA negative-conversion and HBeAg negative-conversion effectively.

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备注/Memo

备注/Memo:
收稿日期：2018-05-21 作者简介：孙曦(1988—)，男，医师。研究方向：肝炎的临床治疗。 △通讯作者：肖璐(1986—)，女，主治医师。研究方向：肝炎的临床治疗。
更新日期/Last Update: 2018-12-15