[1]王皓霖,胡黎文,张金龙,等.真武汤合桂枝茯苓丸治疗肾阳虚型慢性心力衰竭42例[J].西部中医药,2019,32(02):95-98.
　WANG Haolin,HU Liwen,ZHANG Jinlong,et al.ZhenWu Decoction Combined with GuiZhi FuLing Pills in Treating 42 Cases of Chronic Heart Failure of Kidney Yang Deficiency Pattern[J].Western Journal of Traditional Chinese Medicine,2019,32(02):95-98.
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真武汤合桂枝茯苓丸治疗肾阳虚型慢性心力衰竭42例
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
32
期数:
2019年02期
页码:
95-98
栏目:
出版日期:
2019-02-15

文章信息/Info

Title:
ZhenWu Decoction Combined with GuiZhi FuLing Pills in Treating 42 Cases of Chronic Heart Failure of Kidney Yang Deficiency Pattern
文章编号:
1004-6852(2019)02-0095-04
作者:
王皓霖1，胡黎文1，张金龙1，程宏申2，黄路梅2，赵凤林2△
1 湖南中医药大学，湖南 长沙 410208； 2 重庆市垫江县中医院
Author(s):
WANG Haolin1, HU Liwen1, ZHANG Jinlong1, CHENG Hongshen2, HUANG Lumei2, ZHAO Fenglin2△
1 Hunan University of Chinese Medicine, Changsha 410208, China; 2 Dianjiang County TCM Hospital
关键词:
心力衰竭; 慢性; 肾阳虚; 真武汤合桂枝茯苓丸; 心室重构; NT-proBNP
Keywords:
heart failure;  chronic;  kidney Yang deficiency;  ZhenWu decoction joined with GuiZhi FuLing pills;  ventricular remodeling;  NT-proBNP
分类号:
R541.6
文献标志码:
B
摘要:
目的：观察真武汤合桂枝茯苓丸治疗肾阳虚型慢性心力衰竭的临床疗效，并评价其对血浆N端前脑钠肽(NT-proBNP)水平及超声心动图等指标的影响。方法：将80例患者随机分为观察组42例和对照组38例。对照组予以常规西药治疗，观察组在对照组治疗基础上予以真武汤合桂枝茯苓丸治疗。4周为1个疗程，1个疗程后比较2组临床疗效、中医证候疗效及不良反应情况，分析NT-proBNP水平和超声心动图等指标的变化情况。结果：观察组临床疗效、中医证候疗效的总有效率明显高于对照组，差异具有统计学意义(P＜0.05)；血浆NT-proBNP水平2组比较，差异有统计学意义(P＜0.05)。左室舒张末期内径、左室射血分数治疗前后2组组内比较，差异有统计学意义(P＜0.05)；治疗后组间比较差异也有统计学意义(P＜0.05)。安全性指标在治疗前后未见明显变化，差异无统计学意义(P＞0.05)。结论：真武汤合桂枝茯苓丸治疗肾阳虚型慢性心力衰竭临床疗效肯定，具有改善患者症状，改善心功能，抗心室重构的作用，且安全性好。
Abstract:
Objective： To observe clinical effects of ZhenWu decoction joined with GuiZhi FuLing pills in treating chronic heart failure of kidney Yang deficiency pattern, and assess its effects on the levels of NT-proBNP and the indexes of ultrasound cardiogram (UCG). Methods: Eighty patients were randomized into the observation group (42 cases) and the control group (38 cases). The control group accepted conventional therapy of Western medicine, and the observation group were treated by ZhenWu decoction joined with GuiZhi FuLing pills on the foundation of the therapy the control group accepted. Four weeks were one course, the changes of UCG indexes, the levels of NT-proBNP were analyzed, adverse events, clinical effects of TCM syndromes and clinical effects were compared after one course. Results: The observation group was higher than the control group obviously in clinical effects and total effective rate of clinical effects of TCM syndromes, and the difference showed statistical meaning (P＜0.05); the difference was statistically significant in the comparisons of the levels of NT-proBNP between both groups (P＜0.05). There was a significant difference in the comparisons of left ventricular end diastolic diameter (LVEDD) and left ventricular ejection fraction (LVEF) within two groups before and after treating (P＜0.05); the difference showed statistical meaning in the comparison between both groups after treating (P＜0.05). The difference had no statistical meaning since there was no obvious changes of safety indexes before and after treating (P＞0.05). Conclusion: ZhenWu decoction joined with GuiZhi FuLing pills could obtain definite effects in treating chronic heart failure of kidney Yang deficiency pattern, which owns the effects of improving the symptoms and cardiac function of the patients, and antiventricular remodeling with good safety.

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备注/Memo

备注/Memo:
收稿日期：2017-07-07 *基金项目：重庆市垫江县科学技术委员会项目(编号djkjxm2016jsyfysfyy044)；全国基层名老中医专家传承工作室项目［国中药办人教发（2015）25号］。 作者简介：王皓霖(1992—)，男，在读硕士研究生。研究方向：中医内科学。 △通讯作者：赵凤林(1971—)，男，主任医师。研究方向：中医药防治心血管病。
更新日期/Last Update: 2019-02-15