[1]曾露,张蕾,侯海晶,等.杨霓芝教授治疗不同原发病所致慢性肾功能衰竭用药规律[J].西部中医药,2024,37(01):59-64.[doi:10.12174/j.issn.2096-9600.2024.01.14]
　ZENG Lu,ZHANG Lei,HOU Haijing,et al.Professor Yang Nizhi 's Medication Rules of Treatment of Chronic Renal Failure Induced by Different Primary Diseases[J].Western Journal of Traditional Chinese Medicine,2024,37(01):59-64.[doi:10.12174/j.issn.2096-9600.2024.01.14]
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杨霓芝教授治疗不同原发病所致慢性肾功能衰竭用药规律
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
37
期数:
2024年01期
页码:
59-64
栏目:
二次研究
出版日期:
2024-01-15

文章信息/Info

Title:
Professor Yang Nizhi 's Medication Rules of Treatment of Chronic Renal Failure Induced by Different Primary Diseases
作者:
曾露1, 张蕾1,2, 侯海晶1,2, 杨霓芝,
1.广州中医药大学第二临床医学院，广东 广州 510405
2.广州中医药大学第二附属医院，广东 广州 510120
Author(s):
ZENG Lu1, ZHANG Lei1,2, HOU Haijing1,2, Director: YANG Nizhi,
1.The Second Clinical Medical College,Guangzhou University of Chinese Medicine,Guangzhou 510405,China
2.The Second Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510120,China
关键词:
慢性肾衰; 慢性肾炎; 糖尿病肾病; 高血压肾病; 数据挖掘; 中医传承辅助平台; 杨霓芝
Keywords:
chronic renal failure; chronic nephritis; diabetic nephropathy; hypertensive nephropathy; data mining; TCMISS
分类号:
R249
DOI:
10.12174/j.issn.2096-9600.2024.01.14
文献标志码:
A
摘要:
目的利用数据挖掘方法分析杨霓芝教授治疗不同原发病所致慢性肾功能衰竭（chronic renal failure，CRF）的用药规律。 方法通过广东省中医院门诊系统收集2019年杨霓芝教授门诊就诊的CRF患者病案资料，按照不同原发病分类总结，利用中医药传承辅助平台进行用药频次、组方规律及聚类分析。 结果收集慢性肾衰患者137例共410个处方，使用频次最高中药分别是泽兰（374）、黄芪（295）、桃仁（293）、丹参（247）、女贞子（231）。原发病分别为慢性肾炎71例、糖尿病肾病16例、高血压肾病15例、梗阻性肾病15例，痛风性肾病5例，其他15例。不同原发病中医症状出现频次以疲倦、尺弱、舌淡暗、舌淡红、夜尿、乏力、小便泡沫、脉沉细、舌齿痕、腰酸、脉细、眠差最高；药物组合频次最高为桃仁-泽兰，泽兰-黄芪，丹参-泽兰；共获得治疗CRF新处方5个。 结论杨霓芝教授治疗CRF以益气活血为核心；以辨病-辨证-辨症-用药为体系，慢性肾小球肾炎患者多重用清热利湿之品，糖尿病肾病患者多重用补肾固精缩尿之品，高血压肾病患者偏重活血化瘀。
Abstract:
ObjectiveTo analyze the medication rules of professor Yang Nizhi's treatment of chronic renal failure (CRF) induced by different primary diseases using data mining. MethodsThe data of CRF patients in professor Yang Nizhi's outpatient clinic in 2019 were collected via the outpatient system of Guangdong Provincial Hospital of Chinese Medicine,the frequency of use,the rules of prescription composition and cluster analysis were carried out utilizing TCMISS according to the categories of different primary diseases. ResultsAll 137 CRF patients and 410 prescriptions were collected,Chinese medicines with the highest frequency were Zelan (Lycopi herba,374 times),Huangqi (Astragali radix,295 times),Taoren (Persicae semen,293 times),Danshen (Salviae miltiorrhizae radix et rhizoma,247 times) and Nüzhenzi (Ligustri lucidi fructus,231 times) respectively.Primary diseases contained 71 cases of chronic nephritis, 16 diabetic nephritis, 15 cases of hypertensive nephropathy,15 cases of obstructive nephropathy, 5 cases of gouty nephropathy and 15 cases of other diseases.TCM symptoms with the highest frequency of different primary diseases contained fatigue,weak ulnar pulse,light and dark tongue,light and red tongue,nocturnal enuresis,weakness,urine bubble,deep and thin pulse,tongue with tooth marks,lumbar soreness, thin pulse and poor sleep; the drug combinations with the highest frequency were Taoren and Zelan,Zelan and Huangqi,Danshen and Zelan; five new prescriptions for the treatment of chronic nephropathy were obtained. ConclusionProfessor Yang Nizhi's treatment of CRF takes benefiting Qi and promoting blood circulation as the core; with disease differentiation-syndrome differentiation-symptom differentiation-medication as the system,giving the herbs of clearing heat and removing dampness to patients with chronic nephritis,the herbs of invigorating kidney,consolidating essence and arresting urine to the ones with diabetic nephropathy,and the herbs of promoting blood circulation and removing blood stasis to the ones with hypertensive nephropathy.

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备注/Memo

备注/Memo:
曾露（1994—），女，硕士学位。研究方向：慢性肾脏病的中西医防治。国家重点研发计划项目（2018YFC1704100，2018YFC1704102）；广东地区名老中医学术观点、特色诊疗方法和重大疾病防治经验研究——杨霓芝名医工作室（中医科技〔2019〕30号）；国家中医药管理局——杨霓芝全国著名老中医药专家传承工作室资助项目（国中医药人教育便函〔2016〕167号）。
更新日期/Last Update: 2024-01-15