[1]费佳,马源,朱辟疆.朱氏滋脾固肾方Ⅰ号对慢性肾脏病2～4期脾肾气虚证症状评分、SCr及BUN的影响[J].西部中医药,2024,37(08):111-114.[doi:10.12174/j.issn.2096-9600.2024.08.25]
　FEI Jia,MA Yuan,ZHU Pijiang.Effects of Zhu′s Nourishing-spleen Consolidating-kidney Prescription No. 1 on the Scores of Spleen-kidney Qi Deficiency Pattern, SCr and BUN in Stage 2 to 4 Chronic Kidney Disease[J].Western Journal of Traditional Chinese Medicine,2024,37(08):111-114.[doi:10.12174/j.issn.2096-9600.2024.08.25]
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朱氏滋脾固肾方Ⅰ号对慢性肾脏病2～4期脾肾气虚证症状评分、SCr及BUN的影响
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
37
期数:
2024年08期
页码:
111-114
栏目:
临床研究
出版日期:
2024-08-15

文章信息/Info

Title:
Effects of Zhu′s Nourishing-spleen Consolidating-kidney Prescription No. 1 on the Scores of Spleen-kidney Qi Deficiency Pattern, SCr and BUN in Stage 2 to 4 Chronic Kidney Disease
作者:
费佳1, 马源2, 朱辟疆1
1.南京中医药大学镇江附属医院/镇江市中医院，江苏 镇江 212000
2.镇江市中西医结合医院，江苏 镇江 212000
Author(s):
FEI Jia1, MA Yuan2, ZHU Pijiang1
1.Zhenjiang Hospital Affiliated to Nanjing University of Chinese Medicine/Zhenjiang Hospital of TCM, Zhenjiang 212000, China
2.Zhenjiang Hospital of Chinese Traditional and Western Medicine, Zhenjiang 212000, China
关键词:
肾脏病; 慢性; 朱氏滋脾固肾方Ⅰ号; 肾功能; 生活质量; 临床疗效
Keywords:
kidney disease;  chronic; nourishing-spleen consolidating-kidney prescription no.1; renal function; quality of life; clinical effects
分类号:
R256.51
DOI:
10.12174/j.issn.2096-9600.2024.08.25
文献标志码:
B
摘要:
目的探讨朱氏滋脾固肾方Ⅰ号治疗慢性肾脏病（chronic kidney disease，CKD）2～4期脾肾气虚证的临床效果及对症状评分、血清肌酐（Serum creatinine，SCr）、血清尿素氮（blood urea nitrogen，BUN）等指标的影响。 方法选取CKD 2～4期患者60例，依据随机数字表法分为观察组和对照组各30例。对照组采取西医常规治疗，观察组在对照组治疗基础上联合朱氏滋脾固肾方Ⅰ号治疗，两组患者均持续治疗12周，后续治疗在专科门诊随访。比较两组临床效果、症状评分、生活质量评分、肾功能指标水平（SCr、BUN）及不良反应情况。 结果观察组总有效率为86.67%（26/30），高于对照组的60.00%（18/30）（P＜0.05）。治疗后两组各项症状评分、SCr及BUN水平均较治疗前下降（P＜0.05），生活质量评分均上升（P＜0.05），且观察组上述指标下降或上升较对照组显著（P＜0.05）。两组不良反应发生率比较差异无统计学意义（P＞0.05）。 结论朱氏滋脾固肾方Ⅰ号治疗CKD 2～4期脾肾气虚证患者具有显著疗效，可以改善患者肾功能及生活质量。
Abstract:
ObjectiveTo discuss curative effects of Zhu's nourishing-spleen consolidating-kidney prescrip-tion no.1 in the treatment of stage 2 to 4 chronic kidney disease (CKD) of spleen-kidney Qi deficiency pattern and its influence on symptom scores, SCr and blood urea nitrogen (BUN). MethodsSixty patients with stage 2 to 4 CKD were chosen, and divded into the observation group and the control group with 30 cases in each. The control group adopted conventional therapy of Western medicine, and the observation group was treated with Zhu's nourishing-spleen consolidating-kidney prescription no.1 on the foundation of the therapy that the control group accepted, both groups were treated for 12 weeks continuously, and the subsequent therapies were conducted in the specialist clinics and the patients were followed up. To compare clinical effects, symptom scores, the scores of quality of life, the levels of renal function indexes including SCr and BUN, and the incidences of adverse reaction between both groups. ResultsTotal effective rate of the observation group was [86.67%(26/30)], higher than [60.00%(18/30)] of the control group (P<0.05). After the treatment, symptom scores, and the levels of SCr and BUN were lowered than these before the treatment in the two groups (P<0.05), and the scores of quality of life were elevated (P<0.05), and the decrease or the increase in the above indexes of the observation group was more significant than that of the control group (P<0.05). The difference had no statistical meaning in the incidences of the adverse reaction between both groups (P>0.05). ConclusionZhu's nourishing-spleen consolidating-kidney prescription no.1 could obtain noticeable effects in the treatment of stage 2 to 4 CKD, and it could improve the patients' renal function and quality of life.

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备注/Memo

备注/Memo:
费佳（1988—），女，硕士学位，主治医师。研究方向：中西医防治肾脏病的临床及实验研究。2020年度镇江市科技创新资金项目（重点研发计划-社会发展）（SH2020071）；江苏省名老中医药专家传承工作室建设项目（FZ2017030）。
更新日期/Last Update: 2024-08-15