[1]徐冰,王燕杰,王赛楠,等.血府逐瘀汤加减对稳定型心绞痛瘀血痹阻证患者血清学指标及脂质代谢的影响[J].西部中医药,2025,38(10):123-126.[doi:10.12174/j.issn.2096-9600.2025.10.21]
　XU Bing,WANG Yanjie,WANG Sainan,et al.Effects of Modified Xuefu Zhuyu Tang on Serological Indicators and Lipid Metabolism in Patients with Stable Angina Pectoris of Blood Stasis Obstruction Pattern[J].Western Journal of Traditional Chinese Medicine,2025,38(10):123-126.[doi:10.12174/j.issn.2096-9600.2025.10.21]
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血府逐瘀汤加减对稳定型心绞痛瘀血痹阻证患者血清学指标及脂质代谢的影响()

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
38
期数:
2025年10期
页码:
123-126
栏目:
衷中参西
出版日期:
2025-10-15

文章信息/Info

Title:
Effects of Modified Xuefu Zhuyu Tang on Serological Indicators and Lipid Metabolism in Patients with Stable Angina Pectoris of Blood Stasis Obstruction Pattern
作者:
徐冰, 王燕杰, 王赛楠, 柳辉, 孙晓凤
邯郸市第一医院，河北 邯郸 056002
Author(s):
XU Bing, WANG Yanjie, WANG Sainan, LIU Hui, SUN Xiaofeng
Handan First Hospital, Handan 056002, China
关键词:
心绞痛; 血府逐瘀汤; 活性氧物质; 心肌营养素1; 骨膜蛋白; 脂质代谢
Keywords:
angina pectoris; ROS; cardiotrophin-1; chondroprotein; lipid metabolism
分类号:
R256.22
DOI:
10.12174/j.issn.2096-9600.2025.10.21
文献标志码:
B
摘要:
目的观察血府逐瘀汤加减对冠心病稳定型心绞痛（stable angina pectoris，SAP）瘀血痹阻证患者血清学指标及脂质代谢的影响。 方法将瘀血痹阻型SAP患者82例随机分为对照组和治疗组各41例。对照组予常规治疗措施干预，治疗组在对照组基础上予血府逐瘀汤加减治疗，两组均治疗2周。比较两组患者心绞痛发作相关指标（心绞痛发作频次、持续时间以及硝酸甘油用量）、血清学指标［活性氧（reactive oxygen species，ROS）、心肌营养素1（cardiotrophin-1，CT-1）、骨膜蛋白］以及脂质代谢指标［总胆固醇（total cholesterol，TC）、甘油三酯（triglyceride，TG）、高密度脂蛋白胆固醇（high density lipoprotein cholesterol，HDL-C）、低密度脂蛋白胆固醇（low density lipoprotein cholesterol，LDL-C）］和临床疗效。 结果治疗后，两组患者心绞痛发作相关指标均明显改善（P＜0.05），且治疗组改善更明显（P＜0.05）；两组血清ROS、CT-1、骨膜蛋白表达水平，TC、TG、LDL-C表达水平均降低（P＜0.05），HDL-C表达水平均升高（P＜0.05），且治疗组各指标改善程度更明显（P＜0.05）；总有效率治疗组［95.12％（39/41）］高于对照组［75.61％（31/41）］（P＜0.05）。 结论常规治疗措施联合血府逐瘀汤加减治疗瘀血痹阻型SAP患者疗效确切，能够有效缓解患者心绞痛症状，抑制血清ROS、CT-1、骨膜蛋白等指标的异常升高，并有效调节脂质代谢紊乱。
Abstract:
ObjectiveTo observe the effects of modified Xuefu Zhuyu Tang on serological indicators and lipid metabolism in patients with stable angina pectoris (SAP) of blood stasis obstruction pattern. MethodsA total of 82 cases of blood stasis obstruction type of SAP were randomized into the control group and the treatment group with 41 cases in each. The control group received conventional treatment measures, while the treatment group was given modified Xuefu Zhuyu Tang on the foundation of the therapy of the control group, both groups were treated for two weeks. To compare angina attack related indicators (frequency of angina attacks, duration and the dose of glycerin trinitrate, serological indicators such as ROS, CT-1 and chondroprotein, and the indexes of lipid metabolism (TC, TG, HDL-C and LDL-C), alongside clinical effects between the two groups. ResultsAfter the tratment, the significant improvement in angina attack related indicators was observed in the two groups (P<0.05), and the improvement of the treatment group was more noticeable (P<0.05); the expressions of ROS, CT-1 and chondroprotein, together with the expressions of TC, TG and LDL-C reduced in the two groups (P<0.05), the levels of HDL-C were elevated (P<0.05), and the improvements of the indexes of the treatment group were more obvious (P<0.05); total effective rate of the treatment group was [95.12%(39/41)], higher than [75.61%(31/41)] of the control group (P<0.05). ConclusionConventional therapeutic measures combined with modified Xuefu Zhuyu Tang are effective in the treatment of SAP of blood stasis obstruction pattern, which could effectively relieve SAP patients’ symptoms, restrain the abnormal rise of ROS, CT-1 and chondroprotein, and effectively regulate disordered lipid metabolism.

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备注/Memo

备注/Memo:
徐冰（1983—），女，副主任护师。研究方向：老年冠心病稳定型心绞痛的研究。Email：821501834@qq.com。河北省中医药管理局科研计划项目（2022667）。
更新日期/Last Update: 2025-10-15