[1]季东方,张单华,陈凯丽,等.补肾活血方联合非布司他治疗尿酸性肾病临床观察[J].西部中医药,2026,39(02):163-166.[doi:10.12174/j.issn.2096-9600.2026.02.32]
　JI Dongfang,ZHANG Danhua,CHEN Kaili,et al.Clinical Observation on Kidney-tonifying Blood-activating Prescription and Febuxostat Tablets in Treating Uric Acid Nephropathy[J].Western Journal of Traditional Chinese Medicine,2026,39(02):163-166.[doi:10.12174/j.issn.2096-9600.2026.02.32]
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补肾活血方联合非布司他治疗尿酸性肾病临床观察()

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
39
期数:
2026年02期
页码:
163-166
栏目:
衷中参西
出版日期:
2026-02-15

文章信息/Info

Title:
Clinical Observation on Kidney-tonifying Blood-activating Prescription and Febuxostat Tablets in Treating Uric Acid Nephropathy
作者:
季东方1, 张单华2, 陈凯丽3, 邓伟1
1.河南中医药大学第一附属医院，河南 郑州 450000
2.青岛市第八人民医院，山东 青岛 266000
3.河南中医药大学第一临床医学院，河南 郑州 450000
Author(s):
JI Dongfang1, ZHANG Danhua2, CHEN Kaili3, DENG Wei1
1.The First Affiliated Hospital of Henan University of CM, Zhengzhou 450000, China
2.Qingdao Eighth People’s Hospital, Qingdao 266000, China
3.First Clinical Medical School of Henan University of CM, Zhengzhou 450000, China
关键词:
尿酸性肾病; 炎症反应; 补肾活血方; 非布司他
Keywords:
uric acid nephropathy; inflammatory reaction; kidney-tonifying blood-activating prescription; febuxostat tablets
分类号:
R259
DOI:
10.12174/j.issn.2096-9600.2026.02.32
文献标志码:
B
摘要:
目的观察补肾活血方联合非布司他治疗脾肾气虚兼血瘀型尿酸性肾病（uric acid nephropathy，UAN）的临床疗效。 方法选取72例脾肾气虚兼血瘀型UAN患者，按随机数字表法分为对照组和治疗组各36例。对照组予非布司他治疗，治疗组在对照组基础上予补肾活血方治疗，两组均治疗4周。比较两组患者血尿酸（serum uric acid，SUA）、血清肌酐（serum creatinine，SCr）、血尿素氮（blood urea nitrogen，BUN）、白细胞介素1β（Interleukin-1β，IL-1β）、β2微球蛋白（β2-microglobulin，β2-MG）、24 h尿蛋白定量（24-hour urinary protein quantification，24 h UPQ）水平以及中医证候积分和临床疗效。 结果治疗后，两组患者血清SUA、SCr、BUN及IL-1β水平均降低（P＜0.01，P＜0.05），且治疗组SUA、SCr及IL-1β水平低于对照组（P＜0.01，P＜0.05）；尿液β2-MG、24 h UPQ水平以及中医证候积分均降低（P＜0.01，P＜0.05）；总有效率对照组［69.67%（23/33）］低于治疗组［94.12%（32/34）］（P＜0.05）。两组患者治疗期间均未见明显不良反应。 结论补肾活血方联合非布司他治疗脾肾气虚兼血瘀型UAN安全可靠，具有肾脏保护作用，可能与降低SUA、IL-1β水平，改善肾功能，减轻炎症反应有关。
Abstract:
ObjectiveTo survey clinical effects of kidney-tonifying blood-activating prescription and febuxostat tablets in treating uric acid nephropathy (UAN) with spleen-kidney Qi deficiency and blood stasis syndrome. MethodsA total of 72 UAN patients were selected, and randomized to the control group and the treatment group with 36 cases in each. The control group was treated with febuxostat tablets, the treatment group received kidney-tonifying blood-activating prescription in addition to conventional Western medicine, both groups were treated for four weeks. To compare the levels of SUA, SCr, BUN, IL-1β, β2-MG and 24 h UPQ, TCM syndrome scores and clinical effects between the two groups. ResultsAfter the treatment, the two groups demonstrated the decrease in the levels of SUA, SCr, BUN and IL-1β (P<0.01, P<0.05), and the decrease in the levels of SUA, SCr and IL-1β of the treatment group was greater than that of the control group (P<0.01, P<0.05); the levels of β2-MG and 24 h UPQ in the urine and TCM syndrome scores were reduced (P<0.01, P<0.05); total effective rate of the control group was [69.67%(23/33)], lower than [94.12%(32/34)] of the treatment group (P<0.05). No obvious adverse reactions were observed in the two groups during therapeutic period. ConclusionKidney-tonifying blood-activating prescription and febuxostat tablets demonstrated safety and reliability in treating UAN with spleen-kidney Qi deficiency and blood stasis syndrome, it could protect the kidney, possibly related to the decrease of the levels of SUA and IL-1β, the improvements of renal function and the reduction of inflammatory reaction.

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备注/Memo

备注/Memo:
河南省科技厅科技攻关项目（182102311173）；河南省中医药管理局项目（2018ZY2001）。季东方（1986—），男，硕士学位，副主任医师。研究方向：中医药防治老年病。；邓伟（1964—），男，硕士学位，教授，主任医师，硕士研究生导师。研究方向：中医药防治肾病。Email：dengken6401@sina.com。
更新日期/Last Update: 2026-02-15