[1]闵婕,陈文信,李红.益气养阴法治疗桥本甲状腺炎的疗效观察[J].西部中医药,2026,39(05):133-137.[doi:10.12174/j.issn.2096-9600.2026.05.25]
　MIN Jie,CHEN Wenxin,LI Hong.Clinical Observation on Replenishing-Qi Nourishing-Yin Method in the Treatment of Hashimoto′s Thyroiditis[J].Western Journal of Traditional Chinese Medicine,2026,39(05):133-137.[doi:10.12174/j.issn.2096-9600.2026.05.25]
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益气养阴法治疗桥本甲状腺炎的疗效观察()

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
39
期数:
2026年05期
页码:
133-137
栏目:
临床研究
出版日期:
2026-05-15

文章信息/Info

Title:
Clinical Observation on Replenishing-Qi Nourishing-Yin Method in the Treatment of Hashimoto′s Thyroiditis
作者:
闵婕, 陈文信, 李红
上海中医药大学附属龙华医院，上海 200032
Author(s):
MIN Jie, CHEN Wenxin, LI Hong
Longhua Hospital Shanghai University of TCM, Shanghai 200032, China
关键词:
桥本甲状腺炎; 气阴两虚证; 桥本方; 临床研究
Keywords:
Hashimoto’s thyroiditis; and deficiency; formula; clinical study
分类号:
R259
DOI:
10.12174/j.issn.2096-9600.2026.05.25
文献标志码:
B
摘要:
目的观察桥本方治疗桥本甲状腺炎（hashimoto’s thyroiditis，HT）气阴两虚证患者的临床疗效。 方法选取甲状腺功能正常的气阴两虚型HT患者，按随机数字表法分为对照组和试验组，每组37例。对照组予硒酵母治疗，试验组予桥本方治疗，两组均连续治疗12周。比较两组患者临床疗效、中医证候评分、血液相关指标［促甲状腺激素（thyroid stimulating hormone，TSH）、游离三碘甲腺原氨酸（free triiodothyronine，FT3）、游离甲状腺素（free thyroxine，FT4）、甲状腺球蛋白抗体（thyroglobulin antibodies，TGAb）、甲状腺过氧化物酶抗体（thyroid peroxidases antibodies，TPOAb）］、免疫相关指标［干扰素γ（interferon-γ，IFN-γ）、肿瘤坏死因子α（tumor necrosis factor-α，TNF-α）、白细胞介素2（interleukin-2，IL-2）、IL-6、IL-8、IL-10水平］及治疗期间不良反应情况。 结果总有效率试验组［71.43%（25/35）］高于对照组［34.29%（12/35）］（P＜0.01）。治疗后，治疗组患者各项中医证候评分均降低（P＜0.05），试验组低于对照组（P＜0.01）。治疗后，试验组FT3水平较治疗前升高，差异有统计学意义（P＜0.05），对照组治疗前后FT3水平比较差异无统计学意义（P＞0.05）；治疗前后两组患者FT4、TSH水平比较，差异均无统计学意义（P＞0.05）。治疗后，两组患者TGAb、TPOAb水平均降低（P＜0.05），试验组低于对照组（P＜0.01）。治疗后，两组患者IL-2水平均较治疗前降低（P＜0.05），且试验组IFN-γ、TNF-α水平降低（P＜0.05），IL-8水平升高（P＜0.05），试验组IL-8水平高于对照组（P＜0.05）。 结论桥本方能够降低气阴两虚型HT患者中医证候积分，有效改善各项中医证候，其可能通过调节Th1/Th2平衡，降低TGAb、TPOAb滴度，发挥调节机体免疫的作用。
Abstract:
ObjectiveTo observe clinical effects of Qiaoben formula (for replenishing-Qi nourishing-Yin) in the treatment of patients with Qi and Yin deficiency syndrome of Hashimoto’s thyroiditis (HT). MethodsPatients with euthyroid HT of Qi and Yin deficiency type were selected and divided into a control group and an experimental group according to the random number table method, with 37 cases in each group. The control group was treated with selenium yeast, while the experimental group orally took Qiaoben formula. Both groups received continuous treatment for 12 weeks. The clinical efficacy, TCM syndrome scores, blood-related indicators [thyroid stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4), thyroglobulin antibodies (TGAb), thyroid peroxidase antibodies (TPOAb)], immune-related indicators [interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), interleukin-2 (IL-2), IL-6, IL-8, IL-10 levels], and adverse reactions during the treatment period were compared between the two groups. ResultsThe total effective rate in the experimental group [71.43% (25/35)] was higher than that in the control group [34.29% (12/35)] (P<0.01). After treatment, the TCM syndrome scores in the experimental group decreased (P<0.05), and the scores in the experimental group were lower than those in the control group (P<0.01). After treatment, the FT3 level in the experimental group increased compared with before treatment, and the difference was statistically significant (P<0.05), while there was no statistically significant difference in FT3 levels in the control group before and after treatment (P>0.05). Before and after treatment, there were no statistically significant differences in FT4 and TSH levels between the two groups (P>0.05). After treatment, the levels of TGAb and TPOAb in both groups decreased (P<0.05), and the levels in the experimental group were lower than those in the control group (P<0.01). After treatment, the IL-2 levels in both groups decreased compared with before treatment (P<0.05); the levels of IFN-γ and TNF-α in the experimental group decreased (P<0.05); the IL-8 level in the experimental group increased (P<0.05), and the IL-8 level in the experimental group was higher than that in the control group (P<0.05). Conclusion Qiaoben formula could reduce TCM syndrome scores in patients with Qi-Yin deficiency type HT, and effectively improve various TCM syndromes, and it might exert the effects of regulating the body’s immunity by modulating the Th1/Th2 balance and decreasing TGAb and TPOAb titers.

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备注/Memo

备注/Memo:
国家自然科学基金（81373617）；上海市卫生健康委员会中医药科研项目（2020JQ001）；上海市科学技术委员会“科技创新行动计划”（19140904600）；上海市科学技术委员会2018年度医学引导类（中、西医）科技支撑项目（18401900800）。闵婕（1987—），女，博士学位，主治医师。研究方向：中医药防治甲状腺疾病及糖尿病的临床与基础研究。
更新日期/Last Update: 2026-05-15