[1]董敏,瞿东晖,杨雪萍,等.产益康栓对大鼠阴道黏膜刺激及过敏反应的实验研究[J].西部中医药,2013,26(03):19-21.
 DONG Min,QU Donghui,YANG Xueping,et al.Experimental Study of the Effects of ChanY iKang Suppository on the Irritation and Allergy of Vaginal Mucosa in Rats[J].Western Journal of Traditional Chinese Medicine,2013,26(03):19-21.
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产益康栓对大鼠阴道黏膜刺激及过敏反应的实验研究
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
26
期数:
2013年03期
页码:
19-21
栏目:
方药·药理研究
出版日期:
2013-03-15

文章信息/Info

Title:
Experimental Study of the Effects of ChanY iKang Suppository on the Irritation and Allergy of Vaginal Mucosa in Rats
文章编号:
1004-6852(2013)03-0019-03
作者:
董敏1瞿东晖2杨雪萍2潘文3△康开彪3
1 甘肃中医学院,甘肃 兰州 730000;2 甘肃省康复中心医院;3 甘肃省中医药研究院
Author(s):
DONG Min1 QU Donghui2 YANG Xueping2 PAN Wen3△ KANG Kaibiao3
1 Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China; 2 Gansu Province Rehabilitation Hospital; 3 Gansu Province A cademy of Chinese Medicine
关键词:
产益康栓大鼠阴道黏膜刺激试验过敏反应
Keywords:
ChanY iKang suppository rat vaginal mucosa stimulation test allergy
分类号:
R285.5
文献标志码:
A
摘要:
目的:观察产益康栓对大鼠阴道黏膜的刺激及过敏反应,为临床安全用药提供理论依据。方法:①阴道黏膜刺激试验:将 16 只大鼠随机分成单次涂抹组、多次涂抹组,每组 8 只。各组给药剂量为0.4 g/(kg·d)。单次涂抹组:涂抹后 24 小时用温水洗去残留的药物。多次涂抹组:连续 8 天,最后 1 次涂抹 24小时后用温水洗去残留的药物,并分别计算阴道黏膜刺激性反应平均积分值。②大鼠阴道过敏试验:将 24 只大鼠分为产益康栓高、低剂量组,对照组,每组 8 只。产益康栓高、低剂量组分别按 0.8、0.4 g/(kg·d)给药,隔日 1 次,共 5 次。对照组给予同体积 0.9%生理盐水注射液,隔日 1 次,共 5 次。给药 10 天后观察各组大鼠阴道黏膜变化情况。结果:观察期间,单次涂抹组、多次涂抹组活动均正常,无死亡现象,2 组阴道黏膜刺激性反应平均积分值为 0 分和 0.17 分。产益康栓高、低剂量组,对照组大鼠阴道无充血、水肿等症状,致敏率为 0.0%。结论:产益康栓对大鼠阴道黏膜组织无明显的刺激性,未发现明显的过敏反应。
Abstract:
Objective: To provide theoretical evidence for safe medication through observing the effects of ChanY iKang suppository on the irritation and allergy of vaginal mucosa in rats. Method:① Stimulation test of vaginal mucosa: all 16 rats were randomized into the groups of single smearing and smearing for many times, eight rats each group. The dosage given to each group was 0.4 g/ (kg·d). The groups of single smearing: the residual medicine was washed away with warm water in 24 hours after smearing. The groups of smearing for many times: for eight consecutive days, till the last time the residual medicine was washed away with warm water in 24 hours. Average score of irritative response in vaginal mucosa was calculated respectively. ② Vaginal allergic tests of rats: all 24 rats were separated into high and low dose groups of ChanYiKang suppository, blank control group, eight rats each group.High and low dose groups of ChanYiKang suppository were medicated in the dosage of 0.8 g/(kg·d) and 0.4 g/(kg·d),once every other day, for five times. Blank control group received the same volume of 0.9% physiological saline,once every other day, for five times. Changes of vaginal mucosa in all groups were observed in ten days after medi- cating. Result: During the period of observation, the rats in both groups were normal and there was no death. Average scores of irritative response in vaginal mucosa were zero and 0.17. There was no congestion, edema and others happened in high and low dose groups of ChanYiKang suppository as well as blank control group. Sensitization rate was 0.0%. Conclusion: ChanYiKang suppository demonstrates neither obvious irritation nor allgery to vaginal mucosa of rats.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2012-12-05 作者简介:董敏(1985—),女,硕士研究生。研究方向:不孕症的中西医结合诊治。 △通讯作者:潘文(1963—),女,硕士研究生导师,主任医师,中华中医药学会编辑出版分会副主任委员,中华中医药学会科普分会副主任委员,中华中医药学会文化分会常务理事,甘肃省领军人才,甘肃省“555”创新人才,甘肃省卫生厅中青年学术技术带头人,甘肃省中医药学会副会长,甘肃省中医药学会文化专业委员会副主任委员兼秘书长,甘肃省中医药学会仲景学说研究会副主任委员,甘肃省科技期刊专家。研究方向:不孕症的中西医结合治疗。
更新日期/Last Update: 2013-03-15