[1]高晓兰,朱增强,陈彦文,等.当归补血汤加味对血管性痴呆大鼠的脑保护作用研究[J].西部中医药,2013,26(04):22-25.
　GAO Xiaolan,ZHU Zengqiang,CHEN Yanwen,et al.Study on Modified DangGui BuXueTang to Cerebral Protection of Rats with Vascular Dementia[J].Western Journal of Traditional Chinese Medicine,2013,26(04):22-25.
点击复制

当归补血汤加味对血管性痴呆大鼠的脑保护作用研究
分享到：

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
26
期数:
2013年04期
页码:
22-25
栏目:
出版日期:
2013-04-15

文章信息/Info

Title:
Study on Modified DangGui BuXueTang to Cerebral Protection of Rats with Vascular Dementia
文章编号:
1004-6852(2013)04-0022-04
作者:
高晓兰1，朱增强2，陈彦文1，王强1，黄继锋1，刘润1
1 甘肃中医学院人体解剖与组织胚胎学教研室，甘肃 兰州 730000；2 兰州石化总医院肿瘤科
Author(s):
GAO Xiaolan1, ZHU Zengqiang2, CHEN Yanwen1, WANG Qiang1, HUANG Jifeng1, LIU Run1
1 Department of Human A natomy and Histoembryology in Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China; 2 Department of Oncology in General Hospital of Lanzhou Sinopec Group
关键词:
血管性痴呆; 神经生长因子; 学习记忆能力; 当归补血汤加味方; 海马; 大鼠
Keywords:
vascular dementia (VD);  nerve growth factor (NGF);  learning and memory ability; modified DangGui BuXueTang;  hippocampus;  rats
分类号:
R283
文献标志码:
A
摘要:
目的：研究当归补血汤加味方对血管性痴呆(vascular dementia，VD)大鼠的脑保护作用及其机制。方法：采用线栓法制成大鼠 VD 模型。用 Morris 水迷宫来检测 VD 大鼠学习记忆能力的改变，应用免疫组织化学染色法检测 VD 大鼠海马区神经生长因子(nerve growth factor,NGF)的表达，观察当归补血汤加味方对其影响。结果：Morris 水迷宫检测表明 VD 术后大鼠游泳距离和潜伏期明显延长，而 VD 术后当归补血汤加 味方灌胃组大鼠学习记忆能力有所改善；VD 大鼠海马 NGF 免疫反应阳性细胞分布稀疏，数目比假手术对照组及 VD 术后当归补血汤加味方灌胃组明显减少(P＜0.05)；而 VD 术后大鼠当归补血汤加味方灌胃组与假手术对照组海马区 NGF 阳性细胞的表达无明显性差异(P＞0.05)。结论:VD 术后大鼠学习记忆能力下降，而当归补血汤加味方能改善 VD 大鼠学习记忆能力；VD 术后大鼠海马区 NGF 免疫反应阳性细胞的表达降低，当归补血汤加味方能增强脑 VD 大鼠海马区 NGF 阳性细胞的表达，对血管性痴呆大鼠的脑组织具有一定的保护作用。
Abstract:
Objective: To study cerebral protection and its mechanism of modified DangGui BuXueTang in treating rats suffering from vascular dementia (VD). Method: VD models were established with suture occluded method. Changes of learning and memory ability of VD rats were detected with Morris water maze and expressions of nerve growth factor (NGF) in the hippocampus of VD rats were measured with immunohistochemical staining method to observe the effects of modified DangGui BuXueTang on the rats. Result: The detection of Morris water maze indicated that swimming distance and incubation period of rats after operation were prolonged, learning and memory ability of rats in intragastric administration group of modified DangGui BuXueTang after surgery were im- proved; NGF immunoreactive cells in the hippocampus of VD rats were scattering, the number was less than that of sham-operation group and intragastric administration group of modified DangGui BuXueTang after surgery remarkably (P＜0.05); while comparison between sham-operation group and intragastric administration group of modified DangGui BuXueTang after surgery showed no statistical difference in the expressions of NGF positive cells in the hippocampus (P＞0.05). Conclusion: Modified DangGui BuXueTang could improve the learning and memory ability of VD rats when the ability is lowered after surgery; it could also enhance the expressions of NGF positive cells in the hippocampous and protect cerebral tissue of VD rats when the expression is decreased.

相似文献/References:

[1]马腾.透穴疗法联合神经生长因子穴位注射治疗小儿麻痹性斜视50例临床观察[J].西部中医药,2012,25(12):92.
　MA Teng.Clinical Observation on Point-to-point Therapy and Point Injection of Nerve Growth Factor for 50 Cases of Infant Paralytic Strabismus[J].Western Journal of Traditional Chinese Medicine,2012,25(04):92.
[2]李伟伟,王鸣池,于盼盼,等.奥拉西坦联合三七通舒治疗血管性痴呆的临床疗效观察[J].西部中医药,2013,26(02):81.
　LI Weiwei,WANG Mingchi,YU Panpan,et al.Observation on Clinical Effects of Oxiracetam Capsule and SanQi TongShu Capsule in Treating Vascular Dementia[J].Western Journal of Traditional Chinese Medicine,2013,26(04):81.
[3]王保平,张圆,陈怡名,等.龙首参葛丸对血管性痴呆大鼠海马CA1区组织结构变化的影响[J].西部中医药,2019,32(06):6.
　WANG Baoping,ZHANG Yuan,CHEN Yiming,et al.Impact of LongShou ShenGe Pills on the Structural Changes of the Tissue in Hippocampal CAI Region of the Rat with Vascular Dementia[J].Western Journal of Traditional Chinese Medicine,2019,32(04):6.
[4]郭铁,雷励△,程平荣,等.补肾活血片治疗血管性痴呆60例[J].西部中医药,2019,32(06):75.
　GUO Tie,LEI Li,CHENG Pingrong,et al.Treatment for 60 Cases of Vascular Dementia by Kidney-invigorating Blood-activating Tablets[J].Western Journal of Traditional Chinese Medicine,2019,32(04):75.
[5]张慧,张婷,陈锐,等.醒脑方对血管性痴呆大鼠脑组织学习记忆能力的保护作用[J].西部中医药,2020,33(07):20.[doi:10.12174/j.issn.1004-6852.2020.07.05]
　ZHANG Hui,ZHANG Ting,et al.Protective Effects of Xingnao Prescription on Learning and Memory Ability of Brain Tissue in VD Rats[J].Western Journal of Traditional Chinese Medicine,2020,33(04):20.[doi:10.12174/j.issn.1004-6852.2020.07.05]
[6]陈业文,陈炜,吴林,等.基于肠道微生物探讨从脾胃论治血管性痴呆[J].西部中医药,2021,34(04):145.[doi:10.12174/j.issn.2096-9600.2021.04.36]
　CHEN Yewen,CHEN Wei,WU Lin,et al.Discussion on Treating Vascular Dementia from Spleen and Stomach Based on Intestinal Microorganism[J].Western Journal of Traditional Chinese Medicine,2021,34(04):145.[doi:10.12174/j.issn.2096-9600.2021.04.36]
[7]孟胜喜,付剑亮,霍清萍,等.恒清Ⅰ号方联合盐酸多奈哌齐对血管性痴呆患者的作用及其机制研究[J].西部中医药,2021,34(01):1.[doi:10.12174/j.issn.2096-9600.2021.01.01]
　MENG Shengxi,FU Jianliang,HUO Qingping,et al.Study on the Effects of Hengqing Prescription No.1 and Donepezil Hydrochloride on Vascular Dementia and Its Mechanism[J].Western Journal of Traditional Chinese Medicine,2021,34(04):1.[doi:10.12174/j.issn.2096-9600.2021.01.01]
[8]陈静,陈炜,唐秀松,等.基于网络药理学探讨丹参治疗血管性痴呆的作用机制[J].西部中医药,2022,35(11):22.[doi:10.12174/j.issn.2096-9600.2022.11.05]
　CHEN Jing,CHEN Wei,TANG Xiusong,et al.Discussion on the Mechanism of Danshen in the Treatment of Vascular Dementia Based on Network Pharmacology[J].Western Journal of Traditional Chinese Medicine,2022,35(04):22.[doi:10.12174/j.issn.2096-9600.2022.11.05]
[9]崔友祥,刘国华,霍飞飞,等.芪参还五胶囊对血管性痴呆痰瘀互结型患者认知功能及血清标志物的影响[J].西部中医药,2023,36(03):119.[doi:10.12174/j.issn.2096-9600.2023.03.23]
　CUI Youxiang,LIU Guohua,HUO Feifei,et al.Influence of Qishen Huanwu Capsules on Cognitive Function and Serum Marker in Patients with Vascular Dementia of Phlegm Blending with Stasis Pattern[J].Western Journal of Traditional Chinese Medicine,2023,36(04):119.[doi:10.12174/j.issn.2096-9600.2023.03.23]
[10]常慧,史宏硕,司国民.司国民教授基于气、血、水、毒理论辨治血管性痴呆[J].西部中医药,2024,37(02):36.[doi:10.12174/j.issn.2096-9600.2024.02.08]
　CHANG Hui,SHI Hongshuo,SI Guomin.Professor Si Guomin′s Differentiation and Treatment of Vascular Dementia on the Foundation of Qi, Blood, Water and Toxin Theory[J].Western Journal of Traditional Chinese Medicine,2024,37(04):36.[doi:10.12174/j.issn.2096-9600.2024.02.08]

备注/Memo

备注/Memo:
收稿日期：2012-10-15 作者简介：高晓兰(1969—)，女，硕士研究生，讲师。研究方向：神经解剖学。
更新日期/Last Update: 2013-04-15