[1]高晓兰,朱增强,陈彦文,等.当归补血汤加味对血管性痴呆大鼠的脑保护作用研究[J].西部中医药,2013,26(04):22-25.
 GAO Xiaolan,ZHU Zengqiang,CHEN Yanwen,et al.Study on Modified DangGui BuXueTang to Cerebral Protection of Rats with Vascular Dementia[J].Western Journal of Traditional Chinese Medicine,2013,26(04):22-25.
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当归补血汤加味对血管性痴呆大鼠的脑保护作用研究
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《西部中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
26
期数:
2013年04期
页码:
22-25
栏目:
方药·药理研究
出版日期:
2013-04-15

文章信息/Info

Title:
Study on Modified DangGui BuXueTang to Cerebral Protection of Rats with Vascular Dementia
文章编号:
1004-6852(2013)04-0022-04
作者:
高晓兰1朱增强2陈彦文1王强1黄继锋1刘润1
1 甘肃中医学院人体解剖与组织胚胎学教研室,甘肃 兰州 730000;2 兰州石化总医院肿瘤科
Author(s):
GAO Xiaolan1 ZHU Zengqiang2 CHEN Yanwen1 WANG Qiang1 HUANG Jifeng1 LIU Run1
1 Department of Human A natomy and Histoembryology in Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China; 2 Department of Oncology in General Hospital of Lanzhou Sinopec Group
关键词:
血管性痴呆神经生长因子学习记忆能力当归补血汤加味方海马大鼠
Keywords:
vascular dementia (VD) nerve growth factor (NGF) learning and memory abilitymodified DangGui BuXueTang hippocampus rats
分类号:
R283
文献标志码:
A
摘要:
目的:研究当归补血汤加味方对血管性痴呆(vascular dementia,VD)大鼠的脑保护作用及其机制。方法:采用线栓法制成大鼠 VD 模型。用 Morris 水迷宫来检测 VD 大鼠学习记忆能力的改变,应用免疫组织化学染色法检测 VD 大鼠海马区神经生长因子(nerve growth factor,NGF)的表达,观察当归补血汤加味方对其影响。结果:Morris 水迷宫检测表明 VD 术后大鼠游泳距离和潜伏期明显延长,而 VD 术后当归补血汤加 味方灌胃组大鼠学习记忆能力有所改善;VD 大鼠海马 NGF 免疫反应阳性细胞分布稀疏,数目比假手术对照组及 VD 术后当归补血汤加味方灌胃组明显减少(P<0.05);而 VD 术后大鼠当归补血汤加味方灌胃组与假手术对照组海马区 NGF 阳性细胞的表达无明显性差异(P>0.05)。结论:VD 术后大鼠学习记忆能力下降,而当归补血汤加味方能改善 VD 大鼠学习记忆能力;VD 术后大鼠海马区 NGF 免疫反应阳性细胞的表达降低,当归补血汤加味方能增强脑 VD 大鼠海马区 NGF 阳性细胞的表达,对血管性痴呆大鼠的脑组织具有一定的保护作用。
Abstract:
Objective: To study cerebral protection and its mechanism of modified DangGui BuXueTang in treating rats suffering from vascular dementia (VD). Method: VD models were established with suture occluded method. Changes of learning and memory ability of VD rats were detected with Morris water maze and expressions of nerve growth factor (NGF) in the hippocampus of VD rats were measured with immunohistochemical staining method to observe the effects of modified DangGui BuXueTang on the rats. Result: The detection of Morris water maze indicated that swimming distance and incubation period of rats after operation were prolonged, learning and memory ability of rats in intragastric administration group of modified DangGui BuXueTang after surgery were im- proved; NGF immunoreactive cells in the hippocampus of VD rats were scattering, the number was less than that of sham-operation group and intragastric administration group of modified DangGui BuXueTang after surgery remarkably (P<0.05); while comparison between sham-operation group and intragastric administration group of modified DangGui BuXueTang after surgery showed no statistical difference in the expressions of NGF positive cells in the hippocampus (P>0.05). Conclusion: Modified DangGui BuXueTang could improve the learning and memory ability of VD rats when the ability is lowered after surgery; it could also enhance the expressions of NGF positive cells in the hippocampous and protect cerebral tissue of VD rats when the expression is decreased.

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备注/Memo

备注/Memo:
收稿日期:2012-10-15 作者简介:高晓兰(1969—),女,硕士研究生,讲师。研究方向:神经解剖学。
更新日期/Last Update: 2013-04-15