[1]任一杰,张 华△,张喜民,等.复方金银花滴丸质量标准的研究[J].西部中医药,2014,27(06):16-17.
 REN Yijie,ZHANG Hua,ZHANG Ximin,et al.Study on Quality Standard for Compound JinYinHua Dripping Pills[J].Western Journal of Traditional Chinese Medicine,2014,27(06):16-17.
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复方金银花滴丸质量标准的研究
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
27
期数:
2014年06期
页码:
16-17
栏目:
出版日期:
2014-06-15

文章信息/Info

Title:
Study on Quality Standard for Compound JinYinHua Dripping Pills
文章编号:
1004-6852(2014)06-0016-02
作者:
任一杰1张 华2△张喜民1邓月婷1贾继禧1刘洁丽1
1 甘肃陇神戎发药业股份有限公司,甘肃 兰州 730101; 2 兰州市第一人民医院
Author(s):
REN Yijie1, ZHANG Hua2△, ZHANG Ximin1, DENG Yueting1, JIA Jixi1, LIU Jieli1
1 Gansu LongShen RongFa Pharmaceutical Company, Ltd., Lanzhou 730101, China; 2 The First People′s Hospital of Lanzhou City
关键词:
复方金银花滴丸质量标准薄层鉴别含量测定绿原酸
Keywords:
compound JinYinHua dripping pills quality standard thin-layer chromatography content determination chlorogenic acid
分类号:
R284.1
摘要:
目的:建立复方金银花滴丸的质量标准。方法:采用薄层色谱法对处方中黄芩、连翘进行定性鉴别,并应用高效液相色谱法,Hypersil ODS-2(250 mm×4.6 mm,5 μm)色谱柱,以乙腈-0.4%磷酸溶液(11∶89)为流动相,检测波长327 nm,流速1.0 mL/min,测定绿原酸的含量。结果:TCL图谱中可检出黄芩、连翘的特征图谱;绿原酸在22.8~57.0 μg/mL呈良好线性关系(r=0.999 9),平均加样回收率为101.3%,RSD为1.37%。结论:本法简便、准确,可用于复方金银花滴丸的质量控制。
Abstract:
Objective: To establish quality standard of compound JinYinHua dripping pills. Methods: HuangQin (Scutellarid baicalensis Georgi) and LianQiao [Forsythia suspense (Thunb.) Vahl] were determined quantitatively, HPLC was adopted, Hypersil ODS-2(250 mm×4.6 mm, 5 μm) chromatographic column, mobile phase: acetonitrile-0.4% phosphoric acid solution(11:89), detection wavelength was 327 nm, flow rate was 1.0 mL/min, the contents of chlorogenic acid were detected. Results: HuangQin and LianQiao could be detected by TLC; chlorogenic acid demonstrated that better linear relationship in the range between 22.8 and 57.0 μg/mL(r=0.999 9), average recovery rate was 101.3%, RSD was 1.37%. Conclusion: The method, simple and accurate, could be used for quality control of compound JinYinHua dripping pills.

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备注/Memo

备注/Memo:
收稿日期:2013-12-20作者简介:任一杰(1981—),男,工程师。研究方向:新药开发。△通讯作者:张华(1962—),女,副主任药师。研究方向:医院药学。
更新日期/Last Update: 2014-06-15