[1]贾潇,尤从新,颜春鲁,等.祛寒逐风合剂对阳虚型膝骨性关节炎内源性透明质酸水平的影响[J].西部中医药,2018,31(02):85-87.
 JIA Xiao,YOU Congxin,YAN Chunlu,et al.The Influence of QuHan ZhuFeng Mixture on the Levels of Endogenous Hyaluronic Acid of the Patients with Knee Osteoarthritis of Yang Deficiency Pattern[J].Western Journal of Traditional Chinese Medicine,2018,31(02):85-87.
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祛寒逐风合剂对阳虚型膝骨性关节炎内源性透明质酸水平的影响()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
31
期数:
2018年02期
页码:
85-87
栏目:
报道·临证经验
出版日期:
2018-02-15

文章信息/Info

Title:
The Influence of QuHan ZhuFeng Mixture on the Levels of Endogenous Hyaluronic Acid of the Patients with Knee Osteoarthritis of Yang Deficiency Pattern
文章编号:
1004-6852(2018)02-0085-03
作者:
贾潇12尤从新2颜春鲁3柴喜平2
1 天津中医药大学,天津 300000; 2 甘肃省中医院; 3 甘肃中医药大学
Author(s):
JIA Xiao12 YOU Congxin2 YAN Chunlu3 CHAI Xiping2
1 Tianjin University of Traditional Chinese Medicine, Tianjin 300000, China; 2 Gansu Provincial Hospital of Traditional Chinese Medicine; 3 Gansu University of Chinese Medicine
关键词:
骨性关节炎阳虚型祛寒逐风合剂透明质酸钠
Keywords:
osteoarthritis knee Yang deficiency pattern QuHan ZhuFeng mixture sodium hyaluronate
分类号:
R684.3
文献标志码:
B
摘要:
目的:观察口服祛寒逐风合剂对阳虚型膝骨性关节炎(KOA)患者关节液以及血清中透明质酸(HA)含量的影响。方法:将90例患者随机分为A、B、C3组,每组30例。A组口服祛寒逐风合剂,50 mL/次,3次/d;B组关节腔内注射透明质酸钠,2 mL/次,1次/周;C组同时使用A、B2组的治疗方法。3组均连续治疗5周。观察治疗前后关节滑液和血清中HA水平的变化情况。结果:关节液HA水平治疗前3组比较,差异无统计学意义(P>0.05);治疗前后3组组内比较差异有统计学意义(P<0.05);治疗5周后,3组组间比较,差异也有统计学意义(P<0.05)。血清HA水平治疗前3组比较,差异无统计学意义(P>0.05);治疗前后3组组内比较差异有统计学意义(P<0.05);治疗5周后,A、C组与B组比较,差异也有统计学意义(P<0.05)。结论:祛寒逐风合剂治疗阳虚型KOA能升高患者关节滑液中HA的含量,降低血清中HA的含量,其中与透明质酸钠联合应用上述作用更加明显。
Abstract:
Objective: To observe the effects of oral administration of QuHan ZhuFeng mixture on the contents of hyaluronic acid (HA) in joint fluid and the serum of the patients with knee osteoarthritis (KOA) of Yang deficiency pattern. Methods: Ninety patients were randomized into the groups of A, B and C. Group A adopted QuHan ZhuFeng mixture, 50 mL each time, three times per day, group B received sodium hyaluronate by intraarticular injection, 2 mL each time, once per week, and group C adopted therapeutic methods in the group A and B. Three groups were treated for five weeks consecutively. The contents of HA in joint fluid and the serum were observed before and after treating. Results: The difference showed no statistical meaning in the comparisons of the levels of HA in joint fluid before treating among three groups (P>0.05); the difference had statistical meaning in the comparisons within three groups before and after treating (P<0.05), the difference was statistically significant in the comparisons among three groups in five weeks after treating (P<0.05). The difference had no statistical meaning in the comparisons of HA contents in the serum before treating among three groups (P>0.05); the difference presented statistical meaning in the comparison between before and after treating within three groups (P<0.05), when group A and C were compared with group B in five weeks after treating, there was a significant difference (P<0.05). Conclusion: QuHan ZhuFeng mixture could raise HA contents in knee joint synovia and decrease HA contents in the serum in the treatment of the patients with KOA of Yang deficiency pattern, its effects are more obvious when it is combined with sodium hyaluronate.

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备注/Memo

备注/Memo:
收稿日期:2017-08-27 *基金项目:甘肃省中医药管理局科研课题(编号GZK2013-15)。 作者简介:贾潇(1983—),男,在读博士研究生,副主任医师。研究方向:骨与关节疾病的临床诊治。
更新日期/Last Update: 2018-02-15