[1]张玉香,王一强,姜德民,等.清肝祛湿活血方对非酒精性脂肪肝大鼠肠道菌群的影响[J].西部中医药,2022,35(03):19-22.[doi:10.12174/j.issn.2096-9600.2022.03.05]
　ZHANG Yuxiang,WANG Yiqiang,JIANG Demin,et al.Effects of Liver-clearing Damp-eliminating Blood-activating Prescription on Intestinal Flora in Nonalcoholic Fatty Liver Disease Rats[J].Western Journal of Traditional Chinese Medicine,2022,35(03):19-22.[doi:10.12174/j.issn.2096-9600.2022.03.05]
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清肝祛湿活血方对非酒精性脂肪肝大鼠肠道菌群的影响
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
35
期数:
2022年03期
页码:
19-22
栏目:
出版日期:
2022-03-15

文章信息/Info

Title:
Effects of Liver-clearing Damp-eliminating Blood-activating Prescription on Intestinal Flora in Nonalcoholic Fatty Liver Disease Rats
作者:
张玉香1, 王一强1, 姜德民1, 史晓伟2, 杜发强3
1.甘肃卫生职业学院，甘肃 兰州 730300
2.甘肃省中医院
3.甘肃医学院
Author(s):
ZHANG Yuxiang1, WANG Yiqiang1, JIANG Demin1, SHI Xiaowei2, DU Faqiang3
1.Gansu Province Health School, Lanzhou 730050, China
2.Gansu Provincial Hospital of Traditional Chinese Medicine
3.Gansu Medical College
关键词:
非酒精性脂肪肝; 肠道菌群; 清肝祛湿活血方; 实验研究; 大鼠
Keywords:
nonalcoholic fatty liver disease; intestinal flora; liver-clearing damp-eliminating blood-activating prescription; experimental study; rats
分类号:
R318
DOI:
10.12174/j.issn.2096-9600.2022.03.05
文献标志码:
A
摘要:
目的探讨清肝祛湿活血方对非酒精性脂肪肝（nonalcoholic fatty liver disease，NAFLD）大鼠肠道菌群的调节作用。 方法将90只SD大鼠随机分为空白组、模型组、血脂康组及清肝祛湿活血方低、中、高剂量组各15只，造模成功后血脂康组予血脂康混悬液0.1 g/kg，清肝祛湿活血方高、中、低剂量组分别予清肝祛湿活血汤22.5、11.25、5.63 g生药/kg，空白组与模型组予等体积蒸馏水，灌胃第30天、第61天分别收集大鼠粪便，计算每克湿便中大肠杆菌、乳酸杆菌、肠球菌、双歧杆菌的菌落数含量。 结果与空白组比较，给药前各组双歧杆菌、乳酸杆菌的菌落数减少，肠球菌、大肠杆菌菌落数增加（P＜0.05）；与模型组比较，给药后血脂康组及清肝祛湿活血方各剂量组双歧及乳酸杆菌菌落数明显增加（P＜0.05），大肠杆菌和肠球菌菌落数减少且差异有统计学意义（P＜0.05）。 结论清肝祛湿活血方具有明显的肠道菌群调节作用。
Abstract:
ObjectiveTo discuss regulatory effects of liver-clearing damp-eliminating blood-activating prescription (LDBP) on intestinal flora in nonalcoholic fatty liver disease (NAFLD) rats. MethodsAll 90 SD rats were randomized into the blank group, the model group, Xuezhikang group, low, moderate and high doses groups of LDBP, with 15 rats in each group, after successfully modeling, Xuezhikang group was given Xuezhikang suspension, 0.1 g/kg, high, moderate and moderate doses groups of LDBP were given LDBP, 22.5, 11.25 and 5.63 g crude drug/kg, the blank group and the model group adopted the equal volume stilled water, rat feces were collected respectively at the 30th and 61st day after drenching, to calculate colony forming units (cfu) of escherichia coli, lactobacillus, enterococcus, bifidobacterium in per gram of wet stool. ResultsCompared with the blank group, the cfu of bifidobacterium and lactobacillus in different groups lowered, while the cfu of enterococcus and escherichia coli increased before medication (P<0.05); compared with the model group, the cfu of bifidobacterium and lactobacillus increased notably in Xuezhikang group, different doses groups of LDBP after medication (P<0.05), the cfu of escherichia coli and enterococcus reduced, and the difference had statistical meaning (P<0.05). ConclusionLDBP has the obvious regulatory effects on intestinal flora.

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备注/Memo

备注/Memo:
张玉香（1982—），女，硕士学位，讲师。研究方向：消化系统疾病的中医药防治。甘肃省中医药管理局科研项目（GZK-2019-63）。
更新日期/Last Update: 2022-06-24