[1]严其凯,张文贤,李佳霖,等.激素性股骨头坏死发病机制研究进展[J].西部中医药,2024,37(10):71-77.[doi:10.12174/j.issn.2096-9600.2024.10.16]
　YAN Qikai,ZHANG Wenxian,LI Jialin,et al.Research Progress in the Pathogenesis of Steroid-induced Osteonecrosis of the Femoral Head[J].Western Journal of Traditional Chinese Medicine,2024,37(10):71-77.[doi:10.12174/j.issn.2096-9600.2024.10.16]
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激素性股骨头坏死发病机制研究进展
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
37
期数:
2024年10期
页码:
71-77
栏目:
研究进展
出版日期:
2024-10-15

文章信息/Info

Title:
Research Progress in the Pathogenesis of Steroid-induced Osteonecrosis of the Femoral Head
作者:
严其凯1, 张文贤2, 李佳霖1, 廖敏杰2, 郭成龙3, 李建东4
1.甘肃中医药大学，甘肃 兰州 730030
2.甘肃省中医院，甘肃 兰州 730050
3.甘肃中医药大学附属医院，甘肃 兰州 730000
4.武警甘肃总队医院，甘肃 兰州 730050
Author(s):
YAN Qikai1, ZHANG Wenxian2, LI Jialin1, LIAO Minjie2, GUO Chenglong3, LI Jiandong4
1.Gansu University of Traditional Chinese Medicine, Lanzhou 730030, China
2.Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China
3.Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou 730000, China
4.Armed Police Gansu Corps Hospital, Lanzhou 730050, China
关键词:
股骨头坏死; 激素性; 发病机制; 研究进展
Keywords:
osteonecrosis of the femoral head;  steroid; pathogenesis; research progress
分类号:
R274.9
DOI:
10.12174/j.issn.2096-9600.2024.10.16
文献标志码:
A
摘要:
探讨整体观念指导下激素性股骨头坏死（steroid-induced osteonecrosis of the femoral head，SONFH）的分子生物学机理，为SONFH的中医药防治提供理论依据，指出长期大剂量使用激素是导致股骨头坏死的主要病因，发病机制主要与脂质代谢紊乱学说、静脉淤滞骨内高压学说、血管内凝血与血管损伤学说、骨髓间充质干细胞成脂分化学说、骨质疏松学说、骨细胞凋亡学说和基因控制学说等有关。
Abstract:
The application of large dose of hormone for a long term is the main cause for osteonecrosis of the femoral head (SONFH), its pathogenesis is mainly related to lip metabolism disorder theory, the theory of intraosseous hypertension of venous stasis, the theory of intravascular coagulation and vascular injury, as well as the theory of adipogenic differentiation of bone marrow mesenchymal stem cells (BMSCs), the theory of osteoporosis, osteocyte apoptosis theory and gene control theory. The article aims to discuss the molecular and biological mechanism of steroid-induced osteonecrosis of the femoral head (SONFH) under the guidance of holistic concept, which could provide theoretical reference for the prevention and treatment of SONFH with TCM.

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备注/Memo

备注/Memo:
严其凯（1995—），男，硕士学位，医师。研究方向：中医药治疗骨关节疾病。甘肃省自然科学基金（2018-0405-JCC-0871）；兰州市科技计划项目（2019-1-64）。
更新日期/Last Update: 2024-10-15