[1]程晓华,姜华△,徐玉娥,等.三黄中空栓剂的制备及质量标准研究[J].西部中医药,2013,26(05):28-30.
　CHENG Xiaohua,JIANG Hua,XU Yue,et al.Study on Quality Control and Preparation of SanHuang Hollow Suppository[J].Western Journal of Traditional Chinese Medicine,2013,26(05):28-30.
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三黄中空栓剂的制备及质量标准研究
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
26
期数:
2013年05期
页码:
28-30
栏目:
出版日期:
2013-05-15

文章信息/Info

Title:
Study on Quality Control and Preparation of SanHuang Hollow Suppository
文章编号:
1004-6852(2013)05-0028-03
作者:
程晓华1，姜华2△，徐玉娥1，蒋振兴1
1 甘肃省中医院，甘肃 兰州 730050；2 甘肃省中医药研究院
Author(s):
CHENG Xiaohua1, JIANG Hua2△, XU Yu’e1, JIANG Zhenxing1
1 Gansu Province Hospital of Traditional Chinese Medicine, Lanzhou 730050, China; 2 Gansu Province A cademy of Chinese Medicine
关键词:
三黄中空栓; 制备; 质量评定
Keywords:
SanHuang hollow suppository;  preparation;  quality assessment
分类号:
R283.5
文献标志码:
A
摘要:
目的：研究三黄中空栓的制备及质量控制，寻找治疗痔疮的新型中药栓剂。方法：采用水、丙二醇及水和丙二醇的混合液分别做药物分散媒进行试验，以分散度、黏度、沉降度为指标进行考察，同时对外壳基质 PEG1000、PEG4000、十六醇的配比进行优选，以栓剂硬度、形成时间及熔融时间为考察指标，确定基质处方最佳方案，最后将黄芩、黄连、黄柏 3 味中药灌装于半合成脂肪酸酯制成的空心栓壳中，制成三黄中空栓，并对其质量标准进行考察。结果：三黄中空栓各项指标符合标准。结论：制备工艺合理可行，可进行临床研究。
Abstract:
Objective: To find a new type of TCM suppository for hemorrhoids through studying the preparation and quality control of SanHuang hollow suppository. Method: Water, glycol propylene and the mixture as drug dispersion-medium, the experiments were performed by investigating degree of dispersion, viscosity and sedimentation rate, the proportion of shell matrix PEG 1 000, PEG 4 000 and cetanol were optimized, the best prescriptions for matrix were chosen by taking the hardness, forming time and melting time as the indexes, HuangQin (Radix Scutellariae), HuangLian(Coptis chinensis Franch) and Huangbai(Cortex Phellodendri Chinensis) were put into the hollow shell made by semi-synthetic aliphatic ester and quality standard was inspected. Result: The indexes met all the criteria of SanHuang hollow suppository. Conclusion: Technique of preparation, reasonable and feasible, could be used for clinical study.

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备注/Memo

备注/Memo:
收稿日期：2012-11-07 作者简介：程晓华(1979—)，女，主管药师。研究方向：中药制剂。 △通讯作者：姜华(1959—)，女，博士学位，主任药师。研究方向：中(藏)药有效成分筛选及质量分析。
更新日期/Last Update: 2013-05-15