[1]李富欣,于蓓蓓,刘瑾,等.茯黄颗粒的质量标准研究[J].西部中医药,2019,32(02):44-48.
　LI Fuxin,YU Beibei,LIU Jin,et al.Study on Quality Standard of FuHuang Granules[J].Western Journal of Traditional Chinese Medicine,2019,32(02):44-48.
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茯黄颗粒的质量标准研究
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
32
期数:
2019年02期
页码:
44-48
栏目:
出版日期:
2019-02-15

文章信息/Info

Title:
Study on Quality Standard of FuHuang Granules
文章编号:
1004-6852(2019)02-0044-05
作者:
李富欣1，于蓓蓓2，刘瑾2，孙丹丹2，吴雪旖1，闫雪生2△
1 山东中医药大学，山东 济南 250355； 2 山东省中医药研究院
Author(s):
LI Fuxin1, YU Beibei2, LIU Jin2, SUN Dandan2, WU Xueyi1, YAN Xuesheng2△
1 Shandong University of Traditional Chinese Medicine, Jinan 250355, China; 2 Shandong Academy of Chinese Medicine
关键词:
茯黄颗粒; 质量标准; 黄芪甲苷; 马钱苷
Keywords:
FuHuang granules;  quality standard;  astragaloside A;  loganin
分类号:
R282
摘要:
目的：建立中药复方制剂茯黄颗粒的质量标准。方法：采用薄层色谱法(TLC)对处方中茯苓皮、黄芪、桑白皮、酒山萸肉进行鉴别，应用高效液相色谱法(HPLC)测定茯黄颗粒中马钱苷和黄芪甲苷的含量。结果：薄层色谱鉴别专属性强，分离度好；黄芪甲苷在3.295 05～32.950 5 μg呈良好的线性关系，r=0.999 2，加样回收率为98.24%，RSD=1.94%；马钱苷在64.876 8～648.768 μg呈良好的线性关系，r=0.999 5，加样回收率为99.93%，RSD=0.41%。结论：本方法准确可靠、灵敏度高，可用于茯黄颗粒的质量控制。
Abstract:
Objective：To establish quality standard of herbal compound prescription FuHuang granules. Methods: FuLingPi (Indian bread exodermis), HuangQi [Astragalus membranaceus (Fisch.) Bunge.], SangBaiPi (Morus alba L.) and JiuYuRou(common macrocarpium fruit) were identified using TLC, the contents of astragaloside A and loganin were measured using HPLC. Results: TLC showed strong identification and good resolution; astragaloside A presented good linear relationship in the range beween 3.295 05 and 32.950 5 μg, r=0.999 2, sample recovery rate was 98.24%, RSD=1.94%; loganin showed good linear relationship in the range between 64.876 8 and 648.768 μg, r=0.999 5, sample recovery rate was 99.93%, RSD=0.41%. Conclusion: The method, which is accurate, reliable and with high sensitivity, could be used for quality control of FuHuang granules.

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备注/Memo

备注/Memo:
收稿日期：2018-06-07 *基金项目：山东省重点研发计划项目(编号2015GSF119029)。 作者简介：李富欣(1992—)，男，硕士学位。研究方向：中药制剂新剂型及新技术研究。 △通讯作者：闫雪生(1962—)，男，硕士研究生导师，研究员。研究方向：中药制剂新剂型及新技术研究。
更新日期/Last Update: 2019-02-15