[1]崔友祥,刘国华,霍飞飞,等.芪参还五胶囊对血管性痴呆痰瘀互结型患者认知功能及血清标志物的影响[J].西部中医药,2023,36(03):119-123.[doi:10.12174/j.issn.2096-9600.2023.03.23]
　CUI Youxiang,LIU Guohua,HUO Feifei,et al.Influence of Qishen Huanwu Capsules on Cognitive Function and Serum Marker in Patients with Vascular Dementia of Phlegm Blending with Stasis Pattern[J].Western Journal of Traditional Chinese Medicine,2023,36(03):119-123.[doi:10.12174/j.issn.2096-9600.2023.03.23]
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芪参还五胶囊对血管性痴呆痰瘀互结型患者认知功能及血清标志物的影响
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
36
期数:
2023年03期
页码:
119-123
栏目:
出版日期:
2023-03-14

文章信息/Info

Title:
Influence of Qishen Huanwu Capsules on Cognitive Function and Serum Marker in Patients with Vascular Dementia of Phlegm Blending with Stasis Pattern
作者:
崔友祥, 刘国华, 霍飞飞, 王世信, 胡方梅
沧州中西医结合医院，河北 沧州 061000
Author(s):
CUI Youxiang, LIU Guohua, HUO Feifei, WANG Shixin, HU Fangmei
Cangzhou Hospital of Integrated TCM-WM, Cangzhou 061000, China
关键词:
血管性痴呆; 痰瘀互结型; 认知功能; 血清标志物; 芪参还五胶囊
Keywords:
vascular dementia; phlegm blending with stasis pattern; cognitive function; serum markers; capsules
分类号:
R277.7
DOI:
10.12174/j.issn.2096-9600.2023.03.23
文献标志码:
B
摘要:
目的探讨芪参还五胶囊对血管性痴呆（vascular dementia，VD）痰瘀互结型患者认知功能及血清标志物的影响。 方法将痰瘀互结型VD患者80例应用计算机随机数字发生器分为对照组和观察组各40例。对照组应用吡拉西坦片治疗，观察组采用芪参还五胶囊治疗，两组患者均连续服药6周。观察治疗前后两组患者中医证候积分、认知功能［简易智力状态检查量表（Mini-mental state examination，MMSE)］与日常生活能力量表(ability of daily life，ADL)评分、血清神经元特异性烯醇化酶(neuron specific enolase，NSE)、超敏C反应蛋白（high-sensitive C-reactive protein，hs-CRP)、脑源性神经营养因子（brain derived neurotrophic factor，BDNF）、乙酰胆碱(acetylcholine,Ach)、乙酰胆碱酯酶(acetylcholinesterase，AChE)、胆碱乙酰转移酶(choline acetyltransferase，ChAT)水平变化情况及临床疗效。分析血清指标变化与认知功能变化的相关性。 结果治疗后两组患者智能减退、神情呆钝、形盛体胖、呕吐痰涎、唇甲青紫及肌肤甲错症状均较治疗前减轻，观察组效果优于对照组（P＜0.05）。总有效率观察组为90%，高于对照组的60%（P＜0.05）。治疗后两组患者MMSE、ADL评分均升高（P＜0.05），观察组高于对照组（P＜0.05）；血清NSE、hs-CRP及AchE水平均降低（P＜0.05），观察组低于对照组（P＜0.05）；BDNF及Ach、ChAT水平均升高（P＜0.05），观察组高于对照组（P＜0.05）。Pearson相关系数分析显示MMSE、ADL评分均与血清Ach、ChAT、BDNF呈正相关，与血清AchE、NSE及hs-CRP呈负相关，且差异具有统计学意义（P＜0.05）。 结论芪参还五胶囊能改善VD患者临床症状，调节血清NSE、hs-CRP、BDNF与胆碱能神经递质水平，提高认知功能和日常生活功能，效果优于吡拉西坦片。
Abstract:
ObjectiveTo explore the influence of Qishen Huanwu capsules on cognitive function and serum markers in phlegm blending with stasis pattern VD patients. MethodsEighty patients were allocated to the control group and the observation group according to computer random number generator, 40 cases each group. The control group was treated with piracetam tablets, and the observation group with Qishen Huanwu capsules, both groups were medicated for six weeks consecutively. To observe TCM syndrome integrals, cognitive function (MMSE and ADL scores), the levels of serum NSE, hs-CRP, BDNF, Ach, AchE and ChAT and clinical effects before and after treatment between both groups. To analyze the correlation between the changes of serum indicators and cognitive function. ResultsAfter the treatment, hypophrenia, dull look, fatness, vomiting of phlegm-drooling, cyanosis of the lips and nails, and scaly dry skin were relieved than these before the treatment, the observation group was better than the control group (P<0.05). Total effective rate of the observation group was 90%, higher than 60% of the control group (P<0.05). After the treatment, MMSE and ADL scores increased in both groups (P<0.05), the observation group was higher than the control group (P<0.05); the levels of serum NSE, hs-CRP and AchE reduced (P<0.05), the observation group was lower than the control group (P<0.05); the levels of BDNF, Ach and ChAT lifted (P<0.05), the observation group was higher than the control group (P<0.05). Pearson correlation coefficient suggested that MMSE and ADL scores showed positive correlation with the levels of Ach, ChAT and BDNF, negative connection to the levels of AchE, NSE and hs-CRP, and the difference was statistically significant (P<0.05). ConclusionQishen Huanwu capsules could improve clinical symptoms in VD patients, regulate the levels of serum NSE, hs-CRP, BDNF and cholinergic neurotransmitter, raise cognitive function and daily life function, and its effects superior to these of piracetam tablets.

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备注/Memo

备注/Memo:
崔友祥（1985—），男，硕士学位，副主任医师。研究方向：脑系疾病的中西医结合治疗。河北省中医药管理局中医药类科研计划项目（2021333）。
更新日期/Last Update: 2023-03-15