[1]林清,高秀娟,喇孝瑾,等.秦艽醇提取物抗炎镇痛作用的实验研究[J].西部中医药,2013,26(07):28-30.
　LIN Qing,GAO Xiujuan,LA Xiaojin,et al.Experimental Study on Anti-inflammatory and Analgesic Effects of Ethanolic Extract of QinJiao[J].Western Journal of Traditional Chinese Medicine,2013,26(07):28-30.
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秦艽醇提取物抗炎镇痛作用的实验研究
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
26
期数:
2013年07期
页码:
28-30
栏目:
出版日期:
2013-07-15

文章信息/Info

Title:
Experimental Study on Anti-inflammatory and Analgesic Effects of Ethanolic Extract of QinJiao
文章编号:
1004-6852(2013)07-0028-03
作者:
林清，高秀娟，喇孝瑾，孙娜，江春花，姚荣妹，刘慧娟
河北联合大学中医学院，河北 唐山 063000
Author(s):
LIN Qing, GAO Xiujuan, LA Xiaojin, SUN Na, JIANG Chunhua, YAO Rongmei, LIU Huijuan
TCM College of Hebei United University, Tangshan 063000, China
关键词:
秦艽醇提取物; 抗炎; 镇痛
Keywords:
ethanolic extract of QinJiao (radix gentianae macrophyllae);  anti-inflammation;  analgesic effects
分类号:
R283
文献标志码:
A
摘要:
目的：研究秦艽醇提取物的抗炎及镇痛作用。方法：采用二甲苯致小鼠耳廓肿胀，角叉菜胶致大鼠足趾肿胀及冰醋酸致小鼠扭体反应，观察秦艽醇提物的抗炎及镇痛作用。结果：秦艽醇提物能降低二甲苯炎症模型小鼠的耳廓肿胀度(P＜0.01)，对角叉菜胶模型大鼠的急性炎症有一定的抑制作用，从第3小时起足趾容积和肿胀度与模型组比较具有统计学意义(P＜0.05)，秦艽醇提物还能提高小鼠的痛阈，减少冰醋酸致小鼠扭体次数，与模型组比较具有统计学意义(P＜0.05)。结论：秦艽醇提物对二甲苯及角叉菜胶所致的炎症具有一定的抑制作用，同时具有明显的镇痛作用。
Abstract:
Objective: To study anti-inflammatory and analgesic effects of ethanolic extract of QinJiao (radix gentianae macrophyllae). Method: Anti-inflammation and analgesic effects of ethanolic extract of QinJiao were observed with the methods of xylene-induced auricular edema of mice, carrageenin-induced toe swollen of rat and writhing response of mice induced by acetic acid. Result: Ethanolic extract of QinJiao could relieve auricular edema of xylene inflammation mice model(P＜0.01), inhibit acute inflammation of carrageenin rat model, it had statistical meaning in toe volume and swelling degrees from the 3rd hour compared with the model group(P＜0.05), ethanolic extract of QinJiao could improve pain threshold in mice and decrease the torsion times of mice, it presented statistical meaning compared with the model group (P＜0.05). Conclusion: Ethanolic extract of QinJiao could inhibit the inflammation induced by dimethyl benzene and carrageenin, at the same time, it shows notable analgesic effects.

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备注/Memo

备注/Memo:
收稿日期：2012-12-08 作者简介：林清(1983—)，女，硕士学位，助教。研究方向：中药基本理论与临床应用。
更新日期/Last Update: 2013-07-15