[1]李喜香,刘效栓,张小华,等.养阴生肌散急性毒性及全身过敏性实验研究*[J].西部中医药,2014,27(01):29-313.
　LI Xixiang,LIU Xiaoshuan,ZHANG Xiaohua,et al.Acute Toxicity Testing and Systemic Allergic Experiment of YangYin ShengJi Powder[J].Western Journal of Traditional Chinese Medicine,2014,27(01):29-313.
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养阴生肌散急性毒性及全身过敏性实验研究*
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
27
期数:
2014年01期
页码:
29-313
栏目:
出版日期:
2014-01-14

文章信息/Info

Title:
Acute Toxicity Testing and Systemic Allergic Experiment of YangYin ShengJi Powder
文章编号:
1004-6852(2014)01-0029-03
作者:
李喜香1，刘效栓1，张小华1，禚君1，豆金彦1，刘军刚1，高小恒1，张坚2，3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3，张芳丽2，3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3，马岚2，3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3，郑立娟2，3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3，吴迪2，3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3
1 甘肃省中医院药学部，甘肃 兰州 730050； 2 兰州大学基础医学院药理学研究所； 3 甘肃省新药临床前研究重点实验室
Author(s):
LI Xixiang1, LIU Xiaoshuan1, ZHANG Xiaohua1, ZHUO Jun1, DOU Jinyan1, LIU Jungang1, GAO Xiaoheng1,ZHANG Jian2,3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3, ZHANG Fangli2,3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3, MA Lan2,3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3, ZHENG Lijuan2,3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3, WU Di2,3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3' target="_blank" rel="external">3
1 Pharmaceutical Department of Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China; 2 Pharmacological Institute of Basical Medical School of Lanzhou University; 3 Key Lab of Preclinical Study for New Drugs of Gansu Province
关键词:
养阴生肌散; 急性毒性; 全身过敏性; 实验研究
Keywords:
YangYin ShengJi powder;  acute toxicity testing;  systemic allergic experiment;  experimental study
分类号:
R28
文献标志码:
A
摘要:
目的：对养阴生肌散进行安全性试验，为临床安全用药提供依据。方法：将养阴生肌散按1∶0.7配成混悬液，0.02 mL/g灌胃，观察小鼠的急性毒性反应；运用养阴生肌散对豚鼠进行致敏和攻击，观察豚鼠有无全身过敏反应发生。结果：养阴生肌散LD50 未能测出，按照毒理学评价标准，LD50＞1 000 mg/kg，属无毒性物质，本实验剂量增加到12 000 mg/kg仍未出现毒性反应，表明养阴生肌散对小鼠安全无毒；对豚鼠全身过敏反应呈弱阳性。结论：养阴生肌散急性毒性及全身过敏性安全指标基本符合规定要求。
Abstract:
Objective: To provide evidence for clinical use of YangYin ShengJi powder through the safety testing. Methods: YangYin ShengJi powder was prepared into suspension in the ratio of 1 to 0.7, and it was applied to the mice through intragastric administration in the concentration of 0.02mL/g, acute toxicity experments of the mice were performed; guinea pigs were sensitized and attacked by YangYin ShengJi powder, systemic allergic experiment of guinea pigs were observed. Results: LD50 of YangYin ShengJi powder couldn't be tested, according to the standards of toxicological evaluation, the drug was nontoxic, and there was still no toxicity when the dosage in the experiment was increased to 12 000 mg/kg, which presented that it was safe to the mice; the results of systemic allergic experiments were weakly positive. Conclusion: Acute toxicity testing and systemic allergic experiments of YangYinShengJi powder basically conform to specified requirements.

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备注/Memo

备注/Memo:
收稿日期：2013-06-03*基金项目：甘肃省重点中医药科研项目(编号GZK-2010-Z13)作者简介：李喜香(1968—)，女，主任中药师。研究方向：新制剂的研发。
更新日期/Last Update: 2014-01-15