[1]周建,汤喜红.度洛西汀联合通络治痹汤加减治疗膝骨性关节炎41例[J].西部中医药,2020,33(04):109-111.[doi:10.12174/j.issn.1004-6852.2020.04.33]
　ZHOU Jian,TANG Xihong.Duloxetine and Modified Tongluo Zhibi Tang in Treating 41 Cases of Knee Osteoarthritis[J].Western Journal of Traditional Chinese Medicine,2020,33(04):109-111.[doi:10.12174/j.issn.1004-6852.2020.04.33]
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度洛西汀联合通络治痹汤加减治疗膝骨性关节炎41例
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
33
期数:
2020年04期
页码:
109-111
栏目:
出版日期:
2020-04-15

文章信息/Info

Title:
Duloxetine and Modified Tongluo Zhibi Tang in Treating 41 Cases of Knee Osteoarthritis
文章编号:
1004-6852(2020)04-0109-03
作者:
周建，汤喜红
延安市人民医院，陕西 延安 716000
Author(s):
ZHOU Jian, TANG Xihong△
Yan′an City People′s Hospital, Yan′an 716000, China
关键词:
骨关节炎; 膝; 通络治痹汤; 度洛西汀; 疼痛; 炎症因子
Keywords:
osteoarthritis;  knee;  Tongluo Zhibi Tang;  duloxetine;  pain;  inflammatory factors
分类号:
R684.3
DOI:
10.12174/j.issn.1004-6852.2020.04.33
文献标志码:
B
摘要:
目的：观察度洛西汀联合通络治痹汤加减治疗膝骨性关节炎的临床疗效。方法：将81例患者按照就诊顺序随机分为观察组41例、对照组40例，对照组给予度洛西汀进行治疗，初始剂量为每次40 mg，每日1次，之后每次60 mg，观察组在对照组治疗的基础上以通络治痹汤辨证加减治疗，每日1剂，水煎早晚分服。6周后对比两组治疗效果。结果：总有效率观察组为92.7%(38/41)，对照组为75.0%(30/40)，2组比较差异有统计学意义(P＜0.05)。治疗前，两组视觉模拟量表(visual analog scale，VAS)评分、奎森功能演算指数(Lequesne)评分比较，差异均无统计学意义(P＞0.05)；治疗后，两组上述指标均比治疗前有所降低，且观察组降低更为显著，差异均有统计学意义(P＜0.05)。治疗前，两组高敏C反应蛋白（high-sensitivity C-reactive protein，hs-CRP）、白细胞介素6(interleukin-6，IL-6)、白细胞介素18(interleukin-18，IL-18)水平比较，差异均无统计学意义(P＞0.05)；治疗后，两组上述指标均比治疗前有所下降，且观察组下降更为显著，差异均有统计学意义(P＜0.05)。结论：度洛西汀联合通络治痹汤辨证加减治疗膝骨性关节炎，可有效调节炎症因子水平，缓解疼痛程度，临床疗效较显著。
Abstract:
Objective: To explore clinical effects of duloxetine and modified Tongluo Zhibi Tang in treating knee osteoarthritis (KOA). Methods: All 81 patients were randomized into 41 cases of the observation group and 40 cases of the control group according to the visiting order, the control group were treated by duloxetine, initial dose 40 mg each time, once each day, 60 mg each time later,and the observation group by modified Tongluo Zhibi Tang, one dose each day, to compare therapeutic effects between both groups in six weeks. Results: Total effective rate of the observation group was 92.7% (38/41), higher than 75.0% (30/40) of the control group, and the difference had statistical meaning between both groups (P＜0.05). Before treating, the difference had no statistical meaning in VAS score and Lequesne between both groups (P>0.05); after treating, the above indexes of both groups lowered compared with before treating, and the decrease of the observation group was more notable, and the difference showed statistical meaning (P＜0.05). Before treating, the difference had no statistical meaning in the levels of hs-CRP, IL-6 and IL-18 between both groups (P＞0.05); after treating, the above indexes of both groups lowered compared with before treating, and the decrease of the observation group was more notable, and the difference showed statistical meaning (P＜0.05). Conclusion: Duloxetine and modified Tongluo Zhibi Tang based on syndrome differentiation in treating KOA could effectively regulate the levels of inflammatory factors, relieve pain degrees and obtain notable clinical effects.

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备注/Memo

备注/Memo:
收稿日期：2019-06-26*基金项目：延安市科技惠民计划项目（2015HM-05-01）。作者简介：周建(1983—)，男，主治医师。研究方向：内科疾病的中西医结合诊治。△通讯作者：汤喜红(1984—)，女，主治医师。研究方向：内科疾病的中西医结合诊治。
更新日期/Last Update: 2020-04-15