[1]郝月姣,邵静,董会,等.丹红注射液治疗慢性心力衰竭有效性及安全性系统评价[J].西部中医药,2023,36(01):55-61.[doi:10.12174/j.issn.2096-9600.2023.01.15]
　HAO Yuejiao,SHAO Jing,DONG Hui,et al.Evaluation of Clinical Effectiveness and Safety of Danhong Injection in Treating Chronic Heart Failure[J].Western Journal of Traditional Chinese Medicine,2023,36(01):55-61.[doi:10.12174/j.issn.2096-9600.2023.01.15]
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丹红注射液治疗慢性心力衰竭有效性及安全性系统评价
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
36
期数:
2023年01期
页码:
55-61
栏目:
出版日期:
2023-01-15

文章信息/Info

Title:
Evaluation of Clinical Effectiveness and Safety of Danhong Injection in Treating Chronic Heart Failure
作者:
郝月姣1, 邵静2, 董会1, 吴欢1, 吴冠信2
1.河南中医药大学，河南 郑州 450000
2.河南中医药大学第一附属医院，河南 郑州 450000
Author(s):
HAO Yuejiao1, SHAO Jing2, DONG Hui1, WU Huan1, WU Guanxin2
1.Henan University of Chinese Medicine, Zhengzhou 450000, China
2.The First Affiliated Hospital of Henan University of CM, Zhengzhou 450000, China
关键词:
心力衰竭; 慢性; 随机对照试验; 有效性; 安全性; 系统评价; 丹红注射液
Keywords:
heart failure;  chronic; randomized controlled trials; effectiveness; safety; systematic evaluation; injection
分类号:
R2-03
DOI:
10.12174/j.issn.2096-9600.2023.01.15
文献标志码:
A
摘要:
目的系统评价丹红注射液治疗慢性心力衰竭临床有效性及安全性。 方法检索中国知网、维普、万方数据、中国生物医学文献服务系统、PubMed、Embase、the Cochrane Library 7个中英文数据库从建库至2020年3月的丹红注射液治疗慢性心力衰竭的随机对照试验（randomized controlled trial，RCT）文献，并按照纳入、排除标准筛选文献、提取研究相关有效资料，运用RevMan5.3软件进行方法学评价。 结果共纳入16个文献，纳入研究总受试者1599例，其中试验组810例，对照组789例，其纳入研究总体质量不高。Meta分析表明：丹红注射液联合常规西医治疗可更有效地提高患者心功能疗效（OR=3.49，95%CI［2.51，4.84］），提升左心室射血分数（MD=6.27，95%CI［4.7070，7.84］），增加6 min步行距离（MD=42.41，95%CI［26.53，58.29］），并降低血浆B型利钠肽水平（SMD=-1.16，95%CI［-1.48，-0.83］）/氨基末端B型利钠肽前体（SMD=-6.35，95%CI［-9.29，-3.41］）及降低左心室舒张末期内径（MD=-5.98，95%CI［-6.95，-5.00］）。另外，根据治疗疗程差异进行相关亚组分析显示：治疗疗程可能与增加左心室射血分数存在一定关联性。 结论在常规西医治疗基础上加用丹红注射液治疗慢性心力衰竭临床有效性优越，试验组每项观察指标均优于对照组，且不良事件发生较少，安全性相对较好，但纳入研究质量不高，仍需更多高质量研究验证丹红注射液在治疗慢性心力衰竭方面的有效性和安全性。
Abstract:
ObjectiveTo systematically analyze clinical effectiveness and safety of Danhong injection in the treatment of chronic heart failure (CHF). MethodsRandomized controlled trials (RCTs) of Danhong injection in treating CHF were searched from seven databases including CNKI, VIP, WanFang, SinMed, PubMed, Embase and the Cochrane Library between data building time and March, 2020, and the literature was screened according to the inclusion and exclusion standard to extract the research relevant valid data, RevMan 5.3 software was applied to conduct methodological evaluation. ResultsAltogether 16 papers were included, involving 1559 total subjects of the study, including 810 cases in the experiment group and 789 cases in the control group, and the overall quality of the included studies is not high. Meta analysis demonstrated that Danhong injection combined with conventional Western medicine could effectively raise clinical effects of cardiac function (OR=3.49, 95%CI[2.51,4.84]), increase left ventricular ejection fraction (LVEF) (MD=6.27, 95%CI[4.7070, 7.84]), and six-minute walking distance (6MWD) (MD=42.41, 95%CI[26.53, 58.29]), and lower the levels of plasma B natriuretic peptide (SMD=-1.16, 95%CI[-1.48, -0.83])/amino terminal B-type natriuretic peptide precursor (SMD=-6.35, 95%CI[-9.29, -3.41]) and reduce left ventricular end-diastolic diameter (MD=-5.98, 95%CI[-6.95, -5.00]). In addition, according to the difference of treatment course, relevant subgroup analysis showed: therapeutic course might be related to increased LVEF. ConclusionConventional Western medicine plus Danhong injection showed the superior clinical effectiveness in treating CHF, the observational indexes of the trial group are better than these of the control group, with fewer adverse events and relatively good safety, while the quality of the included quality is not high, and more high-quality studies are still needed to verify the effectiveness and safety of Danhong injection in the treatment of CHF.

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备注/Memo

备注/Memo:
郝月姣（1993—），女，硕士学位，医师。研究方向：中医内科。国家自然科学基金（81641147）；河南省中医药科学研究重大专项课题（2018ZYZD08，2019ZY2027）。
更新日期/Last Update: 2023-01-15