[1]霍铭,袁继承.垂盆草水提取物与醇提取物对腹腔肿瘤模型小鼠的抑癌作用[J].西部中医药,2020,33(02):15-17.[doi:10.12174/j.issn.1004-6852.2020.02.04]
　HUO Ming,YUAN Jicheng.Research on Tumor-suppression Effects of Water Extract and Alcohol Extract from Chuipencao on the Mice Model with Intraperitoneal Tumor[J].Western Journal of Traditional Chinese Medicine,2020,33(02):15-17.[doi:10.12174/j.issn.1004-6852.2020.02.04]
点击复制

垂盆草水提取物与醇提取物对腹腔肿瘤模型小鼠的抑癌作用
分享到：

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
33
期数:
2020年02期
页码:
15-17
栏目:
出版日期:
2020-02-15

文章信息/Info

Title:
Research on Tumor-suppression Effects of Water Extract and Alcohol Extract from Chuipencao on the Mice Model with Intraperitoneal Tumor
文章编号:
1004-6852(2018)08-0015-03
作者:
霍铭，袁继承
1 菏泽市中医医院/山东中医药大学附属医院，山东 菏泽 274000；2 菏泽医学专科学校药学与生物制药工程系
Author(s):
HUO Ming1, YUAN Jicheng2△
1Heze City TCM Hospital/Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Heze 274000, China；2Department of Pharmacy and Pharmaceutical Engineering, Heze Medical College
关键词:
腹腔肿瘤; 小鼠; 垂盆草; 水提取物; 醇提取物
Keywords:
intraperitoneal tumor;  mice;  Chuipencao;  water extract;  alcohol extract
分类号:
R73-3
DOI:
10.12174/j.issn.1004-6852.2020.02.04
文献标志码:
A
摘要:
目的：探究垂盆草水提取物与醇提取物对腹腔肿瘤模型小鼠的抑癌作用。方法：建立30只小鼠S180肉瘤模型和S180腹水癌模型，随机分为6组，每组5只，包括对照组(不给药)，垂盆草水提取物低剂量组(给药剂量3.33 g/kg)、高剂量组(给药剂量6.67 g/kg)，垂盆草醇提取物低剂量组(给药剂量3.33 g/kg)、高剂量组(给药剂量6.67 g/kg)，环磷酰胺组(给予环磷酰胺40 mg/kg)。实体瘤模型小鼠统计各组的平均瘤重及抑瘤率。腹水瘤模型小鼠统计各组的平均生存天数及生命延长率。结果：垂盆草用药组及环磷酰胺组的瘤重均显著低于对照组，差异有统计学意义(P＜0.05)；除环磷酰胺组外，垂盆草醇提取物高剂量组的瘤重最低，抑瘤率最高，与其他各组相比差异有统计学意义(P＜0.05)。垂盆草用药组及环磷酰胺组小鼠的生存天数均显著高于对照组，差异均有统计学意义(P＜0.05)；除环磷酰胺组外，垂盆草水提取物低剂量组小鼠的生存天数最长，生命延长率最高，与其他各组相比，差异有统计学意义(P＜0.05)。结论：垂盆草水提取物和醇提取物对小鼠移植性肿瘤均有明显的抑制作用，可延长荷瘤小鼠的生存时间，但提取物剂量与疗效并无明显相关。
Abstract:
Objective: To survey the tumor-suppression effects of water extract and alcohol extract from Chuipencao (Sedum sarmentosum Bunge) on the mice model with intraperitoneal tumor. Methods: Mice models with S180 sarcoma and S180 ascites carcinoma were established and randomized into six groups, five mice each group, including the control group (no medication), low (dosage 3.33 g/kg) and high (dosage 6.67 g/kg) doses groups of water extract from Chuipencao, low(dosage 3.33 g/kg) and high (dosage 6.67 g/kg) doses groups of alcohol extract from Chuipencao, cyclophosphamide group (cyclophosphamide 40 mg/kg), tumor-suppression rate and mean tumor weight of the mouse with solid tumor in different groups were calculated, average survival days and life prolonging rate of the mice models with ascites tumor were counted.Results: The medication group of Chuipencao and cyclophos-phamide group were lower than the control group in the tumor weight notably, and the difference had statistical meaning (P＜0.05); except cyclophosphamide group, the tumor weight of high dose groups of alcohol extract from Chuipencao was the lowest, and tumor suppression rate the highest, the difference had statistical meaning when they were compared with different groups (P＜0.05). The medication group of Chuipencao and cyclophosphamide group were higher than the control group remarkably in survival days, and the difference was statistically significant(P＜0.05); except cyclophosphamide group, the survival days of the mice in low dose group of water extract from Chuipencao were the longest, life prolonging rate the highest, compared with the other groups, there was a significant difference(P＜0.05). Conclusion: Water extract and alcohol extract from Chuipencao show inhibitory effects to the mice with transplanted tumor, they could prolong the survival time of the tumor-bearing mice, while the dose of the extract is not obviously related to curative effects.

相似文献/References:

[1]贡布东智,阿召,何强,等.藏药“五味麝香丸”药效学实验研究[J].西部中医药,2013,26(08):55.
　GONGBU Dongzhi,A Zhao,HE Qiang,et al.Experimental Study on the Pharmacodynamics of Tibetan Drug “WuWei SheXiang Pill"[J].Western Journal of Traditional Chinese Medicine,2013,26(02):55.
[2]王玉珠,王曌滢.止痒油膏外敷止痒作用的实验研究*[J].西部中医药,2013,26(12):15.
　WANG Yuzhu,WANG Zhaoying.Experimental Study on Relieving Itching of ZhiYang Ointment for External Use[J].Western Journal of Traditional Chinese Medicine,2013,26(02):15.
[3]张娟,卿德刚,孙宇,等.复方大枣片增强免疫功能的实验研究*[J].西部中医药,2014,27(03):28.
　ZHANG Juan,QING Degang,SUN Yu,et al.Experimental Study on Compound Jujube Tablets in Improving Immunity[J].Western Journal of Traditional Chinese Medicine,2014,27(02):28.
[4]展锐,黄邦荣,王兰英,等.兰州方对再生障碍性贫血模型小鼠外周血细胞的影响*[J].西部中医药,2014,27(09):10.
[5]马毅,徐丽△,曹军平,等.白藜芦醇对糖尿病小鼠抗应激的实验研究[J].西部中医药,2014,27(12):15.
[6]蔡佳佳,刘振珂,李吉华,等.大鲵肉对D-半乳糖诱发小鼠衰老相关指标的影响[J].西部中医药,2015,28(07):4.
[7]袁娟丽,贺中民.龙星胶囊抗脑缺血作用的实验研究[J].西部中医药,2015,28(10):32.
[8]侯建平,王亚军,严亚峰,等.虎杖提取物抗动物高尿酸血症的实验研究[J].西部中医药,2012,25(05):21.
　HOU Jian-ping,WANG Ya-jun,YAN Ya-feng,et al.Study of Polygonum Cuspidatum Extract on Anti-Hyperuricemia in Rats and Mice[J].Western Journal of Traditional Chinese Medicine,2012,25(02):21.
[9]张炜,韩彪△,刘喜平,等.补阳还五汤对60Coγ射线辐射损伤小鼠外周血T淋巴细胞亚群和IL-2的影响*[J].西部中医药,2014,27(01):17.
　ZHANG Wei,HAN Biao,LIU Xiping,et al.The Influence of BuYang HuanWu Tang on T Lymphocytes and IL-2 in Peripheral Blood of Mice Damaged by 60Co γ Ray Radiation[J].Western Journal of Traditional Chinese Medicine,2014,27(02):17.
[10]张政,邓月婷,王小芳,等.松潘乌头总碱半数致死量的实验研究[J].西部中医药,2016,29(03):19.
　ZHANG Zheng,DENG Yueting,WANG Xiaofang,et al.Experimental Study on Lethal Median Dose of Total Alkaloids of SongPan WuTou[J].Western Journal of Traditional Chinese Medicine,2016,29(02):19.

备注/Memo

备注/Memo:
收稿日期：2018-12-20*基金项目：山东省中医药科技发展计划项目(2013-356)。作者简介：霍铭(1974—)，男，主管药师。研究方向：中药有效成分及质量标准研究。通讯作者：袁继承(1978—)，男，硕士学位，副教授，副主任药师。研究方向：中药制剂研制及其质量标准研究。
更新日期/Last Update: 2020-02-15