[1]陈静,陈炜,唐秀松,等.基于网络药理学探讨丹参治疗血管性痴呆的作用机制[J].西部中医药,2022,35(11):22-31.[doi:10.12174/j.issn.2096-9600.2022.11.05]
　CHEN Jing,CHEN Wei,TANG Xiusong,et al.Discussion on the Mechanism of Danshen in the Treatment of Vascular Dementia Based on Network Pharmacology[J].Western Journal of Traditional Chinese Medicine,2022,35(11):22-31.[doi:10.12174/j.issn.2096-9600.2022.11.05]
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基于网络药理学探讨丹参治疗血管性痴呆的作用机制

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
35
期数:
2022年11期
页码:
22-31
栏目:
出版日期:
2022-11-15

文章信息/Info

Title:
Discussion on the Mechanism of Danshen in the Treatment of Vascular Dementia Based on Network Pharmacology
作者:
陈静1, 陈炜2, 唐秀松1, 伍媛1, 劳祎林1, 吴林1
1.广西中医药大学，广西 南宁 530001
2.广西中医药大学第一附属医院脑病一区
Author(s):
CHEN Jing1, CHEN Wei2, TANG Xiusong1, WU Yuan1, LAO Yilin1, WU Lin1
1.Guangxi University of Chinese Medicine, Nanning 530001, China
2.First Ward of Encephalopathy, the First Affiliated Hospital of Guangxi University of Chinese Medicine
关键词:
血管性痴呆; 网络药理学; 通路; 作用机制; 丹参
Keywords:
vascular dementia; network pharmacology; pathway; mechanism
分类号:
R223.1+3
DOI:
10.12174/j.issn.2096-9600.2022.11.05
文献标志码:
A
摘要:
目的基于网络药理学方法探讨丹参治疗血管性痴呆（vascular dementia，VD）的作用机制。 方法在TCMSP平台检索和筛选丹参的有效成分，运用人类基因数据库（the human gene database,GeneCards）和在线孟德尔人类遗传数据库（online mendelian inheritance in man，OMIM）检索VD的作用靶点，绘制韦恩图，构建蛋白-蛋白相互作用网络(protein-protein interactions，PPI)，并对靶点涉及的生物功能和通路进行分析，构建可视化通路图。 结果从丹参中筛选出54个有效成分，作用于86个VD靶点，丹参治疗VD的核心基因主要有丝氨酸/苏氨酸蛋白激酶1（serine/threonine protein kinase 1，Akt1）、白细胞介素6(interleukin-6，IL-6)、原癌基因（C-FOS）、血管内皮生长因子A(vascular endothelial growth factor A，VEGFA)、丝裂原活化蛋白激酶1(mitogen activated protein kinase 1，MAPK1)等。中药-疾病靶点通过基因本体论功能富集分析（gene ontology，GO）功能共富集到130条生物过程，主要包括G蛋白偶联胺受体活性、肾上腺素能受体活性、核受体活性、转录因子活性，直接配体调节的序列特异性DNA、儿茶酚胺结合等。中药-疾病靶点通过KEGG富集分析（kyoto encyclopedia of genes and genomes，KEGG）通路共有134条，主要包括卡波西肉瘤相关疱疹病毒感染通路、非小细胞肺癌、乙型肝炎病毒通路、白细胞介素17(interleukin-17，IL-17)信号通路等。 结论丹参通过多成分、多靶点和多途径调控VD，该研究结果能为VD的临床治疗及丹参的临床与实验研究提供理论依据。
Abstract:
ObjectiveTo survey the mechanism of Danshen (Salviae miltiorrhizae radix et rhizoma) in treatig VD based on network pharmacology. MethodsThe active ingredients of Danshen were searched and screened in TCMSP, GeneCards and OMIM were used to search the targets of VD, draw Venn diagram, and construct PPI, perform target involved biological function and pathway, as well as construct visual pathway diagrams. ResultsAll 54 active ingredients were screened from Danshen, acting on 86 VD targets, the core genes of Danshen in the treatment of VD mainly contained Akt1, IL-6, C-FOS, VEGFA and MAPK1. TCM-disease targets were enriched to 130 biological processes through GO function, mainly containg the activity of G protein-coupled amine receptor, adrenergic receptor, the nuclear receptor and transcription factor, direct ligand regulation of sequence-specific DNA, catecholamine junctions. There are 134 TCM-disease targets through KEGG pathways, mainly including Kaposi sarcoma-associated herpesvirus infection pathway, non-small cell lung cancer, hepatitis B virus pathway, IL-17 signaling pathway, etc. ConclusionDanshen could regulate VD through multiple components, multiple targets and multiple pathways, and the research results could provide theoretical foundation for clinical therapy of VD, clinical and experimental study of Danshen.

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备注/Memo

备注/Memo:
陈静（1993—），女，在读硕士研究生。研究方向：脑血管病、帕金森病的中医药防治。国家自然科学基金项目（81760847）；广西自然科学基金重点项目（2018GXNSFDA050018）；广西中医药大学一流学科开放课题（2019XK018）；广西中医药大学岐黄工程高层次人才团队培育项目（030030001-04B1804803-500101）；广西中医药大学第一附属医院学术团队（院字2018（146）号）。
更新日期/Last Update: 2022-11-15