[1]王金环,赵雨婷,于海艳,等.补髓生血颗粒对慢性髓劳病患者Kv1.3通道蛋白表达的影响[J].西部中医药,2020,33(05):11-13.[doi:10.12174/j.issn.1004-6852.2020.05.03]
　WANG Jinhuan,ZHAO Yuting,YU Haiyan,et al.Effects of Busui Shengxue Granules on Kv1.3 Channel Expression in CAA Patients[J].Western Journal of Traditional Chinese Medicine,2020,33(05):11-13.[doi:10.12174/j.issn.1004-6852.2020.05.03]
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补髓生血颗粒对慢性髓劳病患者Kv1.3通道蛋白表达的影响
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
33
期数:
2020年05期
页码:
11-13
栏目:
出版日期:
2020-05-15

文章信息/Info

Title:
Effects of Busui Shengxue Granules on Kv1.3 Channel Expression in CAA Patients
文章编号:
1004-6852(2020)05-0011-03
作者:
王金环，赵雨婷，于海艳，沈凤麟，李鹤然，杨思琦
1 黑龙江中医药大学附属第一医院，黑龙江 哈尔滨 150060； 2 黑龙江中医药大学； 3 吉林省吉林中西医结合医院
Author(s):
WANG Jinhuan1, ZHAO Yuting2, YU Haiyan3, SHEN Fenglin2, LI Heran2, YANG Siqi2
1 First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin 150060, China; 2 Heilongjiang University of Chinese Medicine; 3 Jilin Provincial Jilin Hospital of Integrative Medicine
关键词:
髓劳病; 慢性; Kv1.3; 造血微环境; 补髓生血颗粒; 中医药
Keywords:
aplastic anemia;  chronic;  Kv1.3;  hematopoietic microenvironment;  Busui Shengxue granules;  TCM
分类号:
R259
DOI:
10.12174/j.issn.1004-6852.2020.05.03
文献标志码:
A
摘要:
目的：探讨补髓生血颗粒对慢性髓劳病患者骨髓单个核细胞Kv1.3通道蛋白表达的影响。方法：32例慢性髓劳病患者温水冲服补髓生血颗粒,每次1袋，每日3次，连续服用6个月后收集患者及健康人群（n=10）骨髓液4 mL，应用Western blot方法检测慢性髓劳病患者治疗前后及健康人群骨髓单个核细胞Kv1.3通道蛋白。结果：慢性髓劳病患者治疗前Kv1.3通道蛋白表达低于健康人群（P＜0.05)，治疗后Kv1.3通道蛋白表达较治疗前升高，但仍低于健康人群（P＜0.05)。结论：补髓生血颗粒可能通过提高慢性髓劳病患者骨髓单个核细胞Kv1.3通道蛋白表达水平，修复因整合素β1介导的细胞迁移及黏附异常损伤的造血微环境，从而促进骨髓造血干细胞增殖。
Abstract:
Objective: To explore the effects of Busui Shengxue granules (BSSXG) on the expressions of Kv1.3 channel protein of bone marrow mononuclear cells (BMMC) in chronic aplastic anemia (CAA) patients. Methods: All 32 patients took BSSXG orally, one bag every time, three times each day, 4 mL of bone marrow of the patients and healthy people(n=10) were collected after they took the granules for six consecutive months, Western blot method was applied to detect the expressions of Kv1.3 channel protein of BMMC in CAA patients before and after treating and healthy people. Results: Before treating, the expressions of Kv1.3 channel protein in CAA patients were lower than these of healthy people (P＜0.05), after treating, the expressions of Kv1.3 channel protein rose notably than before treating, while lower than these of healthy people (P＜0.05). Conclusion: BSSXG could promote the proliferation of bone marrow hematopoietic stem cells which might be through lifting the expressions of Kv1.3 channel protein of BMMC, repairing hematopoietic microenvironment damaged by abnormal adhesion and cell migration mediated by integrin β 1.

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备注/Memo

备注/Memo:
收稿日期：2019-02-13*基金项目：国家自然科学基金面上项目(81673968)。作者简介：王金环(1977—)，女，博士学位，博士后，主任医师。研究方向：血液病的中医药治疗。
更新日期/Last Update: 2020-05-15