[1]脱承德,李建省△,刘野,等.通脑丸对慢性脑缺血性大鼠血清GSH—Px、MDA含量的影响[J].西部中医药,2012,25(08):23-25.
　TUO Cheng-de,LI Jian-sheng,LIU Ye,et al.Effect of TongNaoWan on Contents of GSH-Px and MDA in Serum of Rat with Chronic Cerebral Ischemia[J].Western Journal of Traditional Chinese Medicine,2012,25(08):23-25.
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通脑丸对慢性脑缺血性大鼠血清GSH—Px、MDA含量的影响
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
25
期数:
2012年08期
页码:
23-25
栏目:
出版日期:
2012-08-15

文章信息/Info

Title:
Effect of TongNaoWan on Contents of GSH-Px and MDA in Serum of Rat with Chronic Cerebral Ischemia
文章编号:
1004-6852(2012)08-0023-03
作者:
脱承德1，2，李建省2△，刘野2，刘国安2，孟庆峰1
1 甘肃中医学院，甘肃 兰州 730000； 2 甘肃省中医院
Author(s):
TUO Cheng-de1，2, LI Jian-sheng2△, LIU Ye2, LIU Guo-an2, MENG Qing-feng1
1 Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China; 2 Gansu Province Hospital of Traditional Chinese Medicine
关键词:
脑缺血; 慢性; 通脑丸; GSH-Px; MDA
Keywords:
cerebral ischemia;  chronic;  TongNaoWan;  GSH-Px;  MDA
分类号:
R743.3
文献标志码:
A
摘要:
目的：观察通脑丸对慢性脑缺血性大鼠血清GSH-Px、MDA含量的影响。方法：采用双侧颈总动脉结扎法(2VO)造模，术后恢复性喂养3周，采用改进后的Bederson评分标准选取造模成功的36只大鼠，随机分成3组：模型组、通脑丸高剂量组和低剂量组，每组12只，空白组12只灌同等剂量的生理盐水，其余各组连续灌胃给药8周后，股动脉取血检测GSH-Px及MDA的含量。结果：模型组与空白组相比，血清GSH-Px活性明显下降(P＜O.01)；血清MDA含量明显升高(P＜0.01)，提示造模成功；通脑丸高、低剂量组与模型组相比，血清GSH-PX活性明显增强(P＜0.01)；血清MDA含量明显降低(P＜0.01)；而通脑丸高、低剂量组之间无统计学意义(P＞0.05)。结论：通脑丸对慢性缺血脑组织具有保护作用，其机制可能通过提高GSH-PX活性，抑制缺血后MDA的升高而实现。
Abstract:
Objective: To survey effects of TongNaoWan on contents of GSH-Px and MDA in serum of rat with chronic cerebral ischemia. Method: Model was established through ligation of bilateral cephalic artery and was restored to feed for three weeks after surgery. Thirty-six rats were chosen according to reformed Bederson evaluation standards and randomly divided into three groups: model group, high, low dose groups of Tong Nao Wan, 12 rats each group. Twelve rats in blank group were administered with same doses of physiological saline while other groups were intragastrically administered with medicine for eight consecutive weeks. Contents of GSH-Px and MDA were detected through drawing blood from femoral artery. Result: Activity of serum GSH-Px obviously decreases (P＜0.01) and content of serum MDA rise significantly(P＜0.01) when model group was compared with blank group, which suggested that the model was established successfully; when TongNaoWan group(high and low dose groups) were compared with model group, activity of serum GSH-Px increased remarkably(P＜0.01); content of serum MDA reduced notably (P＜0.01); comparison between high and low dose groups of Tong Nao Wan showed no statistical meaning(P＞0.05). Conclusion: TongNaoWan can protect tissue of chronic cerebral ischemia, its mechanism might improve the activity of GSH-Px and inhibit the rising of MDA after ishchemia.

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备注/Memo

备注/Memo:
收稿日期：2012-03-21 作者简介：脱承德(1962—)，男，副主任医师。研究方向：心血管疾病的中医药防治。 △通讯作者：李建省(1976—)，男，博士学位，主治医师。研究方向：中医肿瘤方证信号传导研究。
更新日期/Last Update: 2012-08-15