[1]古立新,李长文.中西医结合疗法治疗AECOPD合并呼吸衰竭45例[J].西部中医药,2017,30(12):1-5.
　GU Lixin,LI Changwen.Combined Treatment of TCM and Western Medicine in Treating 45 Cases of AECOPD Complicated with Respiratory Failure[J].Western Journal of Traditional Chinese Medicine,2017,30(12):1-5.
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中西医结合疗法治疗AECOPD合并呼吸衰竭45例
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
30
期数:
2017年12期
页码:
1-5
栏目:
出版日期:
2017-12-15

文章信息/Info

Title:
Combined Treatment of TCM and Western Medicine in Treating 45 Cases of AECOPD Complicated with Respiratory Failure
文章编号:
1004-6852(2017)12-0001-05
作者:
古立新1，李长文2
1 广西中医药大学附属瑞康医院，广西 南宁 530011； 2 广西梧州市龙圩中医医院
Author(s):
GU Lixin1, LI Changwen2
1 Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning 530011, China; 2 Wuzhou Municipality Longxu TCM Hospital
关键词:
肺疾病; 慢性; 阻塞性; 急性加重期; 中西医结合; 呼吸衰竭
Keywords:
pulmonary disease;  chronic;  obstructive;  acute exacerbation;  combined treatment of TCM and western medicine;  respiratory failure
分类号:
R563.8
文献标志码:
A
摘要:
目的：观察中西医结合疗法对AECOPD合并呼吸衰竭患者血清炎症指标、肺功能以及动脉血气的影响。方法：将90例患者随机分为观察组、对照组各45例。对照组予以舒张支气管、糖皮质激素、抗感染配合机械通气治疗；观察组在对照组治疗的基础上给予中药治疗。2组均于治疗10天后测定动脉血气及血清炎症因子，比较临床症状、体征积分及临床疗效。结果：咳嗽、咳痰、喘息及哮鸣音治疗前后2组组内比较，差异有统计学意义(P＜0.05)；治疗后组间比较，差异也有统计学意义(P＜0.05)。最大肺活量(FVC)、峰值呼气流速(PEF)、第一秒用力呼气量(FEV1)、第一秒用力呼气量/最大肺活量(FEV1/FVC)治疗前后2组组内比较，差异有统计学意义(P＜0.05)；治疗后组间比较，差异也有统计学意义(P＜0.05)。pH、动脉血氧分压(PO2)、二氧化碳分压(PCO2)、血氧饱和度(SaO2)治疗前后2组组内比较，差异有统计学意义(P＜0.05)；治疗后组间比较，差异也有统计学意义(P＜0.05)。血清C反应蛋白(CRP)、白细胞介素1β(IL-1β)和白细胞介素8(IL-8)治疗前后2组组内比较，差异有统计学意义(P＜0.05)；治疗后组间比较，差异也有统计学意义(P＜0.05)。总有效率对照组为73.33%，观察组为91.11%，2组比较差异有统计学意义(P＜0.05)。2组间不良反应发生率比较，差异无统计学意义(P＞0.05)。结论：中西医结合疗法治疗AECOPD合并呼吸衰竭的疗效确切，可降低炎症指标，改善肺功能和动脉血气，安全性高。
Abstract:
Objective: To observe the effects of combined treatment of TCM and western medicine on arterial blood gas (ABG), pulmonary function and serum inflammation markers of AECOPD patients complicated with respiratory failure. Methods: Ninety patients were randomized into the observation group and the control group, 45 cases each group. The control group were given the therapies of relaxing bronchus, glucocorticoid, anti-infection and mechanical ventilation, and the observation group accepted herbs on the foundation of the therapy the control group received, clinical effects, clinical symptoms and body sign scales were compared and inflammation markers, and ABG of both groups were detected after they were treated for ten days. Results: The difference had statistical meaning in the comparisons of cough, expectoration, asthma and wheezing rale within two groups before and after treating (P＜0.05); the difference had statistical meaning in the comparison between both groups after treating (P＜0.05). The difference had statistical meaning in the comparison of forced vital capacity(FVC), peak expiratory flow (PEF),forced expiratory volume in first second (FEV1) and FEV1/FVC within two groups before and after treating (P＜0.05); the difference showed statistical meaning in the comparison between both groups after treating (P＜0.05). The difference presented statistical meaning in the comparisons of pH, PO2, PCO2, SaO2 within two groups before and after treating(P＜0.05); the difference showed statistical meaning in the comparison between both groups after treating (P＜0.05). The difference had statistical meaning in the comparisons of CRP, IL-1β and IL-8 within two groups before and after treating (P＜0.05); the difference indicated statistical meaning in the comparisons between both groups after treating (P＜0.05). Total effective rate of the control group was 73.33%, lower than 91.11% of the observation group, and the difference had statistical meaning (P＜0.05). The difference had no statistical meaning in the comparisons of the incidence of adverse reaction between both groups(P＞0.05). Conclusion: Combined treatment of TCM and western medicine could obtain definite effects in treating AECOPD patients complicated with respiratory failure, it could decrease serum inflammation markers, improve pulmonary function and ABG with high safety.

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备注/Memo

备注/Memo:
收稿日期：2017-01-09 *基金项目：广西自然科学基金重点项目(编号2011GXNSFD018039)； 广西科技攻关项目(编号1140003B-93)。 作者简介：古立新(1967—)，男，硕士学位，副主任医师。研究方向：重症医学。
更新日期/Last Update: 2017-12-15